INT187324

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 0.15
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (C4bpa) cytoplasm (C4bpa)
Anatomy Link Frequency
thyroid 1
C4bpa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 6 95.84 Very High Very High Very High
Bile 60 90.84 High High
Opioid 6 90.16 High High
agonist 8 66.28 Quite High
antagonist 8 61.92 Quite High
Hippocampus 16 53.32 Quite High
anesthesia 16 5.00 Very Low Very Low Very Low
Pyramidal cell 14 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Dismenorea 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 6 83.08 Quite High
Cognitive Disorder 6 62.44 Quite High
Toxicity 16 28.96 Quite Low
Body Weight 2 19.32 Low Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low
Stress Incontinence 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
Dysmenorrhea 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BPA interacts with a number of hormone receptor systems, including androgen and thyroid receptors as well as ER-?
BPA Binding (interacts) of in thyroid
1) Confidence 0.14 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0.15 Pain Relevance 0.03
The mean PSSD observed after treatment with the combination of BPA and 17?
BPA Binding (combination) of
2) Confidence 0.11 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0 Pain Relevance 0.06
Thus, we examined the possibility of deconjugation of BPA-GA in fetal tissue.
BPA Binding (deconjugation) of
3) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.04
In the present study, we detected a small amount of BPA-GA and deconjugated BPA in fetal tissues after perfusion with 2 ?
BPA Binding (deconjugated) of
4) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
Although we observed the expression of other UGT isoforms, such as UGT1A1, UGT1A6, and UGT1A7, in the fetus (Figure 6C), the results of the UGT activity assay strongly suggested that the fetus has low ability to metabolize BPA due to a deficiency in UGT2B1.
BPA Binding (metabolize) of
5) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.09
In the present study, we detected a small amount of BPA-GA and deconjugated BPA in fetal tissues after perfusion with 2 ?
BPA Binding (amount) of
6) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
The detection of BPA indicates the possibility that BPA-GA is deconjugated by fetal ?
BPA Binding (deconjugated) of
7) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.05
Incubation of fetal primary cell cultures with BPA-GA
BPA Binding (Incubation) of
8) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
Furthermore, the binding affinity of BPA indicated that it is approximately 10000-fold less potent than E2 and 20000-fold less potent than DES for both ER?
BPA Binding (affinity) of
9) Confidence 0.02 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0.05
Furthermore, the binding affinity of BPA indicated that it is approximately 10000-fold less potent than E2 and 20000-fold less potent than DES for both ER?
BPA Binding (binding) of
10) Confidence 0.02 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0.05

General Comments

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