INT187327

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 0.29
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (C4bpa) cytoplasm (C4bpa)
Anatomy Link Frequency
plasma 2
hepatocytes 1
veins 1
placenta 1
C4bpa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 70 96.04 Very High Very High Very High
Hippocampus 8 40.88 Quite Low
anesthesia 16 5.00 Very Low Very Low Very Low
Pyramidal cell 7 5.00 Very Low Very Low Very Low
Opioid 7 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
nMDA receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 3 70.64 Quite High
Stress Incontinence 7 58.72 Quite High
Congenital Anomalies 7 57.60 Quite High
Cognitive Disorder 3 50.00 Quite Low
Toxicity 16 18.28 Low Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent work has demonstrated that BPA and 17?
Positive_regulation (demonstrated) of BPA
1) Confidence 0.14 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0.07 Pain Relevance 0
Moreover, we previously reported that the amount of BPA-GA excreted in maternal veins is increased by compensatory excretion (Inoue et al. 2004).
Positive_regulation (increased) of BPA in veins
2) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0.12 Pain Relevance 0.05
When coupled with the relatively long gestation period in humans, such compensatory increases in plasma BPA-GA could increase the risk of placental transfer of BPA-GA, even though maternal exposures may be low.
Positive_regulation (increases) of BPA in plasma
3) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.04
This low level of UGT activity may induce delay of metabolism toward deconjugated BPA in the fetus.
Spec (may) Positive_regulation (induce) of BPA
4) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
However, during pregnancy, the concentration of BPA-GA in maternal blood may be increased because of an increase in venous excretion by hepatocytes.
Positive_regulation (increased) of BPA in hepatocytes
5) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.09
When coupled with the relatively long gestation period in humans, such compensatory increases in plasma BPA-GA could increase the risk of placental transfer of BPA-GA, even though maternal exposures may be low.
Positive_regulation (increase) of BPA in plasma
6) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.04
This suggests that the concentration of BPA-GA in maternal blood is increased for the entire gestational period and that, consequently, there is an increased risk of BPA-GA transfer across the placenta.
Positive_regulation (increased) of BPA in placenta
7) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0.11 Pain Relevance 0.05
Leaching of BPA out of the products is increased by heating (Krishnan et al. 1993), contact with alkaline substances (Olea et al. 1996), and deterioration of the products (Howdeshell et al. 2003), and BPA is thus widely released into the environment.
Positive_regulation (increased) of BPA
8) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

General Comments

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