INT187327

Context Info Confidence 0.14 First Reported 2005 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 2 Total Number 8 Disease Relevance 0.29 Pain Relevance 0.27

extracellular region (C4bpa) cytoplasm (C4bpa)

Anatomy Link Frequency plasma 2 hepatocytes 1 veins 1 placenta 1 C4bpa (Rattus norvegicus)

Pain Link Frequency Relevance Heat Bile 70 96.04 Hippocampus 8 40.88 anesthesia 16 5.00 Pyramidal cell 7 5.00 Opioid 7 5.00 antagonist 3 5.00 ketamine 2 5.00 agonist 2 5.00 nMDA receptor 1 5.00

Disease Link Frequency Relevance Heat Aging 3 70.64 Stress Incontinence 7 58.72 Congenital Anomalies 7 57.60 Cognitive Disorder 3 50.00 Toxicity 16 18.28 Body Weight 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recent work has demonstrated that BPA and 17?

Positive_regulation (demonstrated) of BPA

1) Confidence 0.14 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0.07 Pain Relevance 0

Moreover, we previously reported that the amount of BPA-GA excreted in maternal veins is increased by compensatory excretion (Inoue et al. 2004).

Positive_regulation (increased) of BPA in veins

2) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0.12 Pain Relevance 0.05

When coupled with the relatively long gestation period in humans, such compensatory increases in plasma BPA-GA could increase the risk of placental transfer of BPA-GA, even though maternal exposures may be low.

Positive_regulation (increases) of BPA in plasma

3) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.04

This low level of UGT activity may induce delay of metabolism toward deconjugated BPA in the fetus.

Spec (may) Positive_regulation (induce) of BPA

4) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

However, during pregnancy, the concentration of BPA-GA in maternal blood may be increased because of an increase in venous excretion by hepatocytes.

Positive_regulation (increased) of BPA in hepatocytes

5) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.09

When coupled with the relatively long gestation period in humans, such compensatory increases in plasma BPA-GA could increase the risk of placental transfer of BPA-GA, even though maternal exposures may be low.

Positive_regulation (increase) of BPA in plasma

6) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.04

This suggests that the concentration of BPA-GA in maternal blood is increased for the entire gestational period and that, consequently, there is an increased risk of BPA-GA transfer across the placenta.

Positive_regulation (increased) of BPA in placenta

7) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0.11 Pain Relevance 0.05

Leaching of BPA out of the products is increased by heating (Krishnan et al. 1993), contact with alkaline substances (Olea et al. 1996), and deterioration of the products (Howdeshell et al. 2003), and BPA is thus widely released into the environment.

Positive_regulation (increased) of BPA

8) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.