INT187328

Context Info Confidence 0.12 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 6 Disease Relevance 0.07 Pain Relevance 0.26

extracellular region (C4bpa) cytoplasm (C4bpa)

Anatomy Link Frequency body 1 hepatic vein 1 C4bpa (Rattus norvegicus)

Pain Link Frequency Relevance Heat Bile 50 100.00 Hippocampus 8 99.00 Pyramidal cell 7 97.60 Opioid 5 40.96 anesthesia 12 5.00 antagonist 3 5.00 ketamine 2 5.00 agonist 2 5.00 nMDA receptor 1 5.00

Disease Link Frequency Relevance Heat Cognitive Disorder 3 68.16 Toxicity 12 38.00 Stress Incontinence 5 5.00 Congenital Anomalies 5 5.00 Aging 3 5.00 Body Weight 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Significant inhibitory effects of BPA were observed at a dose of only 40 ?

Negative_regulation (effects) of BPA

1) Confidence 0.12 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1257590 Disease Relevance 0.07 Pain Relevance 0.14

However, we also previously showed that the UGT activity toward BPA in pregnant rats on GD19.0 were decreased to about 70% of that of nonpregnant adult rats (Matsumoto et al. 2002).

Negative_regulation (decreased) of BPA

2) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

Generally, adult animals are able to metabolize and eliminate BPA from the body.

Negative_regulation (eliminate) of BPA in body

3) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.07

Metabolism of BPA in the fetus

Negative_regulation (Metabolism) of BPA

4) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

These results indicate that BPA-GA is deconjugated to BPA in the fetus.

Negative_regulation (deconjugated) of BPA

5) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

We previously reported that the excretion rate of BPA-GA from the liver into bile is decreased and that compensatory excretion of BPA-GA into the hepatic vein is increased in rodents during pregnancy (Inoue et al. 2004), and we hypothesize that this may also occur in humans.

Negative_regulation (decreased) of BPA in hepatic vein associated with bile

6) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.05

General Comments

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