INT187328

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.07
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (C4bpa) cytoplasm (C4bpa)
Anatomy Link Frequency
body 1
hepatic vein 1
C4bpa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 50 100.00 Very High Very High Very High
Hippocampus 8 99.00 Very High Very High Very High
Pyramidal cell 7 97.60 Very High Very High Very High
Opioid 5 40.96 Quite Low
anesthesia 12 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
nMDA receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 3 68.16 Quite High
Toxicity 12 38.00 Quite Low
Stress Incontinence 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 5 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant inhibitory effects of BPA were observed at a dose of only 40 ?
Negative_regulation (effects) of BPA
1) Confidence 0.12 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1257590 Disease Relevance 0.07 Pain Relevance 0.14
However, we also previously showed that the UGT activity toward BPA in pregnant rats on GD19.0 were decreased to about 70% of that of nonpregnant adult rats (Matsumoto et al. 2002).
Negative_regulation (decreased) of BPA
2) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
Generally, adult animals are able to metabolize and eliminate BPA from the body.
Negative_regulation (eliminate) of BPA in body
3) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.07
Metabolism of BPA in the fetus
Negative_regulation (Metabolism) of BPA
4) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
These results indicate that BPA-GA is deconjugated to BPA in the fetus.


Negative_regulation (deconjugated) of BPA
5) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
We previously reported that the excretion rate of BPA-GA from the liver into bile is decreased and that compensatory excretion of BPA-GA into the hepatic vein is increased in rodents during pregnancy (Inoue et al. 2004), and we hypothesize that this may also occur in humans.
Negative_regulation (decreased) of BPA in hepatic vein associated with bile
6) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.05

General Comments

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