INT187358

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Context Info
Confidence 0.72
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.65
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcnn3) cytoplasm (Kcnn3)
Anatomy Link Frequency
brain 1
neuromuscular junction 1
Kcnn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 18 90.68 High High
Neuronal excitability 14 88.40 High High
Dopamine 23 83.44 Quite High
monoamine 3 82.16 Quite High
long-term potentiation 30 78.40 Quite High
GABAergic 11 75.36 Quite High
Neurotransmitter 8 69.68 Quite High
potassium channel 12 54.12 Quite High
Migraine 14 51.04 Quite High
headache 5 46.32 Quite Low
Disease Link Frequency Relevance Heat
Disease 29 100.00 Very High Very High Very High
Anorexia 10 97.24 Very High Very High Very High
Manic Depressive Disorder 13 97.02 Very High Very High Very High
Schizophrenia 45 96.62 Very High Very High Very High
Anxiety Disorder 7 71.60 Quite High
Headache 16 51.04 Quite High
Eating Disorder 73 50.00 Quite Low
Phobia 4 50.00 Quite Low
Drug Dependence 3 26.32 Quite Low
Urological Neuroanatomy 3 16.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The same factors that prompted the investigations on the possible genetic links between KCNN3 and schizophrenia or bipolar disorder (physiological role of SK3 in neurons, expression pattern of SK3 in brain, polymorphic CAG-repeats in the SK3 amino-terminal region and chromosomal localization of the SK3 gene; see above) led also to studies on its possible involvement in anorexia.
Localization (localization) of SK3 in brain associated with manic depressive disorder, anorexia and schizophrenia
1) Confidence 0.72 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.85 Pain Relevance 0.05
Moreover, immunohistochemical analysis has suggested that SK3 might be localized in presynaptic terminals at the neuromuscular junction [44] and in hippocampal neuronal cultures [45].
Localization (localized) of SK3 in neuromuscular junction
2) Confidence 0.67 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.07
Trinucleotide polymorphism in SK3 and psychiatric diseases
Localization (diseases) of SK3 associated with disease
3) Confidence 0.63 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.72 Pain Relevance 0.16
Using high-resolution immunofluorescence analysis, one study [18] found that the SK3 clusters were precisely colocalized with the presynaptic marker synapsin and at close range (0.4–0.5 mum) from NMDA-receptors and PSD-95, but rarely associated with GABAA-receptor clusters.
Localization (colocalized) of SK3
4) Confidence 0.51 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1260012 Disease Relevance 0.07 Pain Relevance 0.23

General Comments

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