INT18736

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Context Info
Confidence 0.59
First Reported 1990
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 19
Total Number 25
Disease Relevance 4.44
Pain Relevance 8.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ptpn6) phosphatase activity (Ptpn6) cell proliferation (Ptpn6)
nucleus (Ptpn6) cytoplasm (Ptpn6)
Anatomy Link Frequency
brain 3
blood 1
eye 1
tail 1
Ptpn6 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 269 100.00 Very High Very High Very High
Opioid 175 100.00 Very High Very High Very High
analgesia 140 100.00 Very High Very High Very High
Enkephalin 14 100.00 Very High Very High Very High
Kappa opioid receptor 2 99.98 Very High Very High Very High
Dynorphin 142 99.92 Very High Very High Very High
Desipramine 2 99.92 Very High Very High Very High
Antinociceptive 147 99.68 Very High Very High Very High
midbrain 7 99.68 Very High Very High Very High
Central nervous system 37 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 184 100.00 Very High Very High Very High
Pressure And Volume Under Development 69 100.00 Very High Very High Very High
Sprains And Strains 62 97.80 Very High Very High Very High
Neuropathic Pain 21 94.56 High High
Targeted Disruption 21 94.24 High High
Anxiety Disorder 2 94.20 High High
Depression 1 93.84 High High
Brain Hemorrhage 7 89.76 High High
Neuroblastoma 1 89.72 High High
Hyperalgesia 14 85.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Male IRC mice received a single intraperitoneal injection of either the ME, desipramine or diazepam.
Gene_expression (injection) of ME associated with desipramine
1) Confidence 0.59 Published 2008 Journal Phytother Res Section Abstract Doc Link 18386251 Disease Relevance 0.19 Pain Relevance 0.18
Chronic sustained exogenous infusion of the endogenously produced opioid peptide ME is associated with loss of the cardioprotection that is observed with 24 h of infusion.
Gene_expression (produced) of ME associated with enkephalin and opioid
2) Confidence 0.46 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15550529 Disease Relevance 0.47 Pain Relevance 1.11
Our results clearly showed that ME induces the rearrangement of retinogeniculate projections in the mouse dLGN even after eye-specific segregation is mostly complete, and that there is a critical period for this rearrangement.
Gene_expression (induces) of ME in eye
3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0.07 Pain Relevance 0.17
It was unclear how rapidly the rearrangement of retinogeniculate projections occurs in response to ME, to what extent retinogeniculate projections can expand in the dLGN, and whether there are any preferential directions in which RGC axons extend in response to ME.
Gene_expression (expand) of ME
4) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0.06
The distribution patterns of presynaptic markers in the dLGN after ME
Gene_expression (after) of ME
5) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0.04
The size of the CTB-positive area was significantly larger in ME-treated animals than in control animals (ME, 43,673±5,990 µm2, n?
Gene_expression (larger) of ME
6) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
In contrast, when ME was performed at P22, there was only a subtle increase in the CTB-positive area (ME, 15.5±1.2%, n?
Gene_expression (area) of ME
7) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
The size of the CTB-positive area was significantly larger in ME-treated animals than in control animals (ME, 43,673±5,990 µm2, n?
Gene_expression (larger) of ME
8) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
ME at P34 did not have an apparent effect upon the size of the CTB-positive area (ME, 13.6±0.5%, n?
Gene_expression (size) of ME
9) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
In contrast, when ME was performed at P22, there was only a subtle increase in the CTB-positive area (ME, 15.5±1.2%, n?
Gene_expression (performed) of ME
10) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882329 Disease Relevance 0 Pain Relevance 0
Intact MBH slice cultures were initially imaged on the EM-CCD camera to confirm the location of PER2::LUC expression in the Arc, ME/PT and DMH, and then placed in PMTs.
Gene_expression (expression) of ME associated with aids-related complex
11) Confidence 0.11 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.63 Pain Relevance 0
Food deprivation alters the phase of peak PER2::LUC in the ME/PT
Gene_expression (/) of ME
12) Confidence 0.09 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.47 Pain Relevance 0
Control ME did not reduce edema and did not produce irritant effects (data not shown).
Neg (not) Gene_expression (produce) of ME associated with pressure and volume under development
13) Confidence 0.09 Published 2002 Journal Lipids Health Dis Section Body Doc Link PMC139966 Disease Relevance 0.59 Pain Relevance 0.03
M 5,11,14 20:3 ME, or with only 15 ?
Gene_expression (20:3) of ME
14) Confidence 0.09 Published 2002 Journal Lipids Health Dis Section Body Doc Link PMC139966 Disease Relevance 0.07 Pain Relevance 0
Firstly, a great deal of derivatives of opioid peptides have been designed and synthesized, some of which exhibit significant improvements in both the blood–brain barrier penetration and half-life time in blood compared with the parent compounds, which predict the potential product of protein drugs arriving at the central nervous system; some stable peptide analogues of both ME and endomorphin-2 (Egleton et al., 1998), that lead to analgesia without side effects were successfully synthesized (Fichna et al., 2005).
Gene_expression (synthesized) of ME in blood associated with central nervous system, opioid and analgesia
15) Confidence 0.08 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.41 Pain Relevance 1.00
Though ME and ?
Gene_expression (Though) of ME
16) Confidence 0.08 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.06 Pain Relevance 0.92
The selective action of Bestatin might indicate the regional differences of ME catabolism in the brain and also differences in the contribution of APN to the inactivation of ME and LE.
Gene_expression (catabolism) of ME in brain
17) Confidence 0.08 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.26 Pain Relevance 0.43
It was surprised to note that Bestatin, which controlled the ME level in the midbrain, had no effect on the concentration of this peptide in the striatum, nor on the LE concentration in both parts of the brain studied.
Gene_expression (level) of ME in brain associated with midbrain
18) Confidence 0.08 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.29 Pain Relevance 0.42
It was also proved that ME hydrolyzing enzymes were involved in the degradation of not only ME but also ?
Gene_expression (hydrolyzing) of ME
19) Confidence 0.08 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.05 Pain Relevance 1.15
On the other hand, the different metabolisms between ME and LE in the brain were investigated (Belyaev et al., 1990).
Spec (investigated) Gene_expression (metabolisms) of ME in brain
20) Confidence 0.08 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.34 Pain Relevance 0.41

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