INT187360

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 2.51
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnn2)
Anatomy Link Frequency
neurons 3
pyramidal neurons 2
spines 2
pyramidal cells 1
dentate gyrus 1
Kcnn2 (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 77 99.74 Very High Very High Very High
Pyramidal cell 332 99.68 Very High Very High Very High
long-term potentiation 252 99.24 Very High Very High Very High
nMDA receptor 141 98.24 Very High Very High Very High
Hippocampus 86 97.52 Very High Very High Very High
Limbic system 33 96.80 Very High Very High Very High
midbrain 64 95.04 Very High Very High Very High
Glutamate receptor 30 94.12 High High
Calcium channel 32 91.00 High High
Action potential 312 82.96 Quite High
Disease Link Frequency Relevance Heat
Eating Disorder 73 98.60 Very High Very High Very High
Congenital Anomalies 13 97.52 Very High Very High Very High
Drug Induced Neurotoxicity 15 97.12 Very High Very High Very High
Targeted Disruption 48 92.28 High High
Schizophrenia 215 91.84 High High
Hyperemia 15 88.76 High High
Increased Venous Pressure Under Development 34 85.52 High High
Cognitive Disorder 21 84.32 Quite High
Appetite Loss 13 73.24 Quite High
Syndrome 8 70.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This truncated protein was shown to have a nuclear localization and suppress the expression of SK2-mediated currents in Jurkat cells [232].
Gene_expression (expression) of SK2
1) Confidence 0.55 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.72 Pain Relevance 0
In situ hybridization and immunohistochemistry studies on brain tissue from adult rat and mouse have shown further that the SK1, SK2 and SK3 channel subunits have partially overlapping but clearly distinct distribution patterns, with SK1 and SK2 frequently expressed in the same neurons, and SK3 presenting a complementary distribution [32, 34–36].
Gene_expression (expressed) of SK2 in neurons
2) Confidence 0.55 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.07
Detection of RNA by Northern analysis, in situ hybridization or RT-PCR analysis and protein by immunohistochemistry have revealed that SK1, SK2, and SK3 channels are expressed in the central (CNS) and peripheral (PNS) nervous system [18, 31–38], while IK seems not to be present in central neurons, but is expressed in blood and epithelial cells [19–21, 39], and in peripheral sensory, sympathetic and enteric neurons [37, 38, 40–43].
Gene_expression (expressed) of SK2 in nervous system
3) Confidence 0.55 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.04
Cultured microglial cells from rat and mouse brain have been shown to express both SK (SK2, SK3) and IK channels [173, 174].
Gene_expression (express) of SK2 in microglial cells
4) Confidence 0.55 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.10 Pain Relevance 0.07
Pyramidal neurons in the neocortex and in the hippocampal formation display high levels of SK1 and SK2 mRNA [32, 83] and protein [35, 36], while neurons in the basolateral amygdala express all three SK channel subunits [32, 36].
Gene_expression (levels) of SK2 mRNA in neurons associated with pyramidal cell and amygdala
5) Confidence 0.55 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.07 Pain Relevance 0.33
This is interesting because PKA regulates the surface expression of SK2 channels heterologously expressed in COS7 cells.
Gene_expression (expression) of SK2
6) Confidence 0.55 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.23
Taken together, these findings suggest that BDNF might facilitate the induction of LTP by inhibiting SK-mediated currents possibly through the reduction of SK2 surface expression in CA1 pyramidal neurons [96, 117].
Gene_expression (expression) of SK2 in pyramidal neurons associated with pyramidal cell and long-term potentiation
7) Confidence 0.48 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.26
Two subunits leading to the formation of channels highly (SK2) or less sensitive (SK3) to apamin are expressed in subthalamic neurons [32, 36].
Gene_expression (expressed) of SK2 in neurons
8) Confidence 0.48 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.18
In the basolateral amygdala, where both SK2 and SK3 subunits are expressed [32], SK channels activated by somatic depolarizations mediate the mAHP, but do not regulate spike frequency adaptation [112].
Gene_expression (expressed) of SK2 in amygdala associated with amygdala
9) Confidence 0.43 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.05 Pain Relevance 0.55
The reduction in the surface expression of SK2 channels in dendritic spines and consequent potentiation of NMDA-mediated currents, together with the increase in AMPA receptor surface expression, would contribute the synaptic strengthening underlying LTP induction in CA1 neurons [84].
Gene_expression (expression) of SK2 in spines associated with long-term potentiation
10) Confidence 0.43 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.30
Overexpression of SK1 and SK2 subunits, as well as the application of 1-EBIO, lead to a selective enhancement of the apamin-sensitive IAHP [93, 94], while this current is strongly reduced in layer 5 pyramidal neurons from transgenic mice expressing a truncated form of the SK3 subunit that acts in a dominant negative fashion and suppresses the expression of all SK and IK channels [94].
Gene_expression (Overexpression) of SK2 in pyramidal neurons associated with targeted disruption and pyramidal cell
11) Confidence 0.43 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.09 Pain Relevance 0.25
A recent study found that while SK2 and SK3 channels are present only in the endothelium, IK channels are expressed both in endothelial and smooth muscle cells of middle cerebral arteries [187].
Gene_expression (present) of SK2 in smooth muscle cells
12) Confidence 0.43 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.17 Pain Relevance 0
This is interesting because PKA regulates the surface expression of SK2 channels heterologously expressed in COS7 cells.
Gene_expression (expressed) of SK2
13) Confidence 0.43 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.23
In the CA1 stratum radiatum, SK2 has further been shown to be present in dendritic spines, in close proximity to NMDA receptors by double immunogold labeling [84].
Gene_expression (present) of SK2 in spines associated with nmda receptor
14) Confidence 0.42 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.24
Only low level SK2 immunoreactivity is present in the stratum lucidum and dentate gyrus, while high levels have been reported in scattered interneurons in the stratum oriens and radiatum [35, 36], in agreement with the presence of SK2 mRNA [85].
Gene_expression (present) of SK2 in dentate gyrus
15) Confidence 0.37 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0 Pain Relevance 0.23
Studies have also shown that blocking SK channels facilitates the induction of LTP (Behnisch and Reymann, 1998; Stackman et al., 2002) and that genetic overexpression of SK2 channels inhibits LTP induction and hippocampal-dependent learning (Hammond et al., 2006).
Gene_expression (overexpression) of SK2 associated with long-term potentiation
16) Confidence 0.26 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.49
Of the three SK channels, SK1 and SK2 are predominantly expressed in the nervous system, in cortical pyramidal cells; [37] the basal ganglia and limbic system; [26,38,39] dopaminergic (DA) midbrain neurons; [40] and supraoptic neurosecretory cells [41].
Gene_expression (expressed) of SK2 in pyramidal cells associated with pyramidal cell, midbrain and limbic system
17) Confidence 0.25 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1260012 Disease Relevance 1.31 Pain Relevance 0.17
The application of apamin has previously been shown to facilitate the induction of LTP (Behnisch and Reymann, 1998; Lin et al., 2008; Ngo-Anh et al., 2005; Stackman et al., 2002) and genetic overexpression of SK2 channels inhibits the induction of LTP (Hammond et al., 2006).
Gene_expression (overexpression) of SK2 associated with long-term potentiation
18) Confidence 0.20 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.29

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