INT187411

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 12.10
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cd320) molecular_function (Cd320) biological_process (Cd320)
Anatomy Link Frequency
plasma 6
liver 2
hepatocytes 1
fat 1
lipid droplets 1
Cd320 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 264 99.36 Very High Very High Very High
Bile 83 92.64 High High
alcohol 58 88.72 High High
Pain 73 88.68 High High
imagery 62 87.76 High High
anesthesia 5 75.80 Quite High
Endocannabinoid 12 67.12 Quite High
Potency 3 66.20 Quite High
Inflammation 235 50.00 Quite Low
methotrexate 4 45.36 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 810 100.00 Very High Very High Very High
Metabolic Syndrome 162 99.76 Very High Very High Very High
Diabetes Mellitus 116 99.32 Very High Very High Very High
Fatty Liver 279 99.10 Very High Very High Very High
Repression 10 96.96 Very High Very High Very High
Hepatocellular Cancer 38 96.56 Very High Very High Very High
Insulin Resistance 147 95.64 Very High Very High Very High
Hepatitis C Virus Infection 1 93.80 High High
Hepatitis 6 93.28 High High
Coronary Heart Disease 90 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After an initial steep fall in plasma free fatty acids after ingestion of plain crystalline niacin, however, their levels rebound 2 h later, whereas hepatic production of VLDL remains suppressed for several additional hours (Wang et al 2001).
Gene_expression (production) of VLDL in plasma
1) Confidence 0.75 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605342 Disease Relevance 0.80 Pain Relevance 0
Generally, plasma free fatty acid levels appear to increase production of VLDL, especially in states of elevated free fatty acids and VLDL overproduction (eg, obesity or diabetes).
Gene_expression (production) of VLDL in plasma associated with diabetes mellitus and metabolic syndrome
2) Confidence 0.75 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605342 Disease Relevance 0.58 Pain Relevance 0
In human hepatocytes, FATP4 knockdown decreased C18:1 incorporation into phospholipids and VLDL synthesis, suggesting an anabolic role of FATP4 in energy metabolism [33].
Gene_expression (synthesis) of VLDL in hepatocytes
3) Confidence 0.75 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.26 Pain Relevance 0.15
In NAFLD, the NEFA pool contributes equally to the liver TAG and VLDL TAG even though NAFLD patients have a reduced ability to increase VLDL production during fasting, suggesting that NAFLD patients have a limited capacity to adapt to metabolic changes that occur during cycles of fasting and feeding [23].
Gene_expression (production) of VLDL in liver associated with fatty liver
4) Confidence 0.75 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 1.10 Pain Relevance 0
on VLDL production.
Gene_expression (production) of VLDL
5) Confidence 0.75 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.22 Pain Relevance 0.07
In addition to suppressing VLDL production, PPAR?
Gene_expression (production) of VLDL
6) Confidence 0.75 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.28 Pain Relevance 0.17
may diminish VLDL production by favoring fatty acids storage in cytosolic lipid droplets rather than directing through VLDL assembly [203].
Gene_expression (production) of VLDL in lipid droplets
7) Confidence 0.75 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.27 Pain Relevance 0.07
LDL-Cholesterol = Serum Total cholesterol - (HDL- Cholesterol 1 VLDL-Cholesterol)

Statistical analysis

Gene_expression (analysis) of VLDL associated with disorder of lipid metabolism
8) Confidence 0.65 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2881655 Disease Relevance 0.56 Pain Relevance 0.03
-VLDL labelled with99mTc was studied in vitro in rabbits.
Gene_expression (labelled) of VLDL
9) Confidence 0.65 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 0.87 Pain Relevance 0.08
They reported that in addition to decreasing plasma TC, LDL-C, VLDL-C and TG values, this treatment also increased hepatic and intestinal TG when the MTPi was administered with food and when it was dosed away from meals, only hepatic TG were influenced.
Gene_expression (values) of VLDL in plasma
10) Confidence 0.65 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1262701 Disease Relevance 0.14 Pain Relevance 0
, thereby leading to efficient delivery of FA for VLDL assembly and secretion [43].
Gene_expression (assembly) of VLDL
11) Confidence 0.65 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.23 Pain Relevance 0
Generally, plasma free fatty acid levels appear to increase production of VLDL, especially in states of elevated free fatty acids and VLDL overproduction (eg, obesity or diabetes).
Gene_expression (overproduction) of VLDL in plasma associated with diabetes mellitus and metabolic syndrome
12) Confidence 0.65 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605342 Disease Relevance 0.63 Pain Relevance 0
For example, the plasma VLDL and LDL levels do not increase and the HDL levels are elevated upon high-fat diet feeding, which findings are in contrast to those often noted in humans [5].
Gene_expression (levels) of VLDL in fat associated with disorder of lipid metabolism
13) Confidence 0.65 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.65 Pain Relevance 0
The enzyme cholesteryl ester transfer protein (CETP) exchanges CE from HDL-C for TG in LDL-C and VLDL.
Gene_expression (exchanges) of VLDL associated with disorder of lipid metabolism
14) Confidence 0.65 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.35 Pain Relevance 0.05
ligands reduce VLDL production and enhance the catabolism of TG-rich particles, which indirectly decreases small dense LDL (sdLDL) particles, enhancing the formation of HDL particles and hepatic elimination of excess cholesterol [Lefebvre et al., 2006].
Gene_expression (production) of VLDL associated with disorder of lipid metabolism
15) Confidence 0.58 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.89 Pain Relevance 0.11
Statins inhibit HMG-CoA reductase, the rate-limiting step in cholesterol biosynthesis, resulting in increased LDLr density with decreases in LDL, IDL, and VLDL particle synthesis (Farnier 1998; Segrest et al 2000).
Gene_expression (synthesis) of VLDL associated with disorder of lipid metabolism
16) Confidence 0.58 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.96 Pain Relevance 0.03
was ascribed to induction of genes involved in fatty acid oxidation and the concomitant reduction in lipid availability for VLDL production.
Gene_expression (production) of VLDL
17) Confidence 0.58 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.27 Pain Relevance 0.13
This recombination results in the termination of hepatic VLDL synthesis and depletion of plasma apoB100, as described [6].
Gene_expression (synthesis) of VLDL in plasma
18) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.38 Pain Relevance 0.14
Regulation of lipid metabolism is mainly coordinated by liver, which actively metabolizes fatty acids as fuel and continuously produces very low-density lipoproteins (VLDLs) particles to provide a constant supply of fatty acids to peripheral tissues.
Gene_expression (produces) of VLDL in liver
19) Confidence 0.58 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.05 Pain Relevance 0.08
lowers plasma TG in part by reducing very low-density lipoprotein (VLDL) production [194].
Gene_expression (production) of VLDL in plasma
20) Confidence 0.58 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.30 Pain Relevance 0.10

General Comments

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