INT187418

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.83
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (MTTP) transport (MTTP) small molecule metabolic process (MTTP)
Golgi apparatus (MTTP) lipid metabolic process (MTTP)
Anatomy Link Frequency
plasma 2
intestine 2
MTTP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 33 94.24 High High
Pain 3 84.32 Quite High
depression 3 82.24 Quite High
tolerance 3 75.56 Quite High
Inflammation 30 5.00 Very Low Very Low Very Low
methotrexate 12 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
spastic colon 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 150 99.36 Very High Very High Very High
Cancer 63 97.24 Very High Very High Very High
Stress 15 92.44 High High
Adhesions 6 87.84 High High
Infection 18 85.60 High High
Pain 3 84.32 Quite High
Appetite Loss 6 83.92 Quite High
Cognitive Disorder 3 83.12 Quite High
Fever 12 82.88 Quite High
Chills 9 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The microarray results showed that the expression of the gene encoding MTP (probeset 205675_at on the Affymetrix U113A microarray and indicated by UniGene reference Hs.195799) was increased by 19.3%, as a result of the exposure to L. plantarum.
Positive_regulation (increased) of Gene_expression (expression) of MTP
1) Confidence 0.18 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0 Pain Relevance 0
Because of this, we speculate that due to MTP inhibition, less TG were transferred to the chylomicron particle being packaged in the intestine.
Positive_regulation (transferred) of Gene_expression (transferred) of MTP in intestine
2) Confidence 0.17 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1262701 Disease Relevance 0.06 Pain Relevance 0
The fatty acid binding protein FABP1 was upregulated in the 6-h exposure study, as was the microsomal and ER-localized triglyceride transfer protein, MTP, which is discussed in more detail below.
Positive_regulation (upregulated) of Gene_expression (microsomal) of MTP
3) Confidence 0.15 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.34 Pain Relevance 0
The fatty acid binding protein FABP1 was upregulated in the 6-h exposure study, as was the microsomal and ER-localized triglyceride transfer protein, MTP, which is discussed in more detail below.
Positive_regulation (upregulated) of Gene_expression (microsomal) of ER-localized triglyceride transfer protein
4) Confidence 0.15 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.34 Pain Relevance 0
B, which enables the survival of certain cancer cells and provides a mechanism by which they might become resistant to chemotherapy and radiotherapy.24 Clinical investigations, however, suggest that L-MTP-PE might result in a net positive effect in patients treated for osteosarcoma.3,25


Positive_regulation (effect) of Gene_expression (result) of MTP-PE associated with cancer and osteogenic sarcomas
5) Confidence 0.12 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893760 Disease Relevance 1.48 Pain Relevance 0.26
B, which enables the survival of certain cancer cells and provides a mechanism by which they might become resistant to chemotherapy and radiotherapy.24 Clinical investigations, however, suggest that L-MTP-PE might result in a net positive effect in patients treated for osteosarcoma.3,25


Positive_regulation (-) of Gene_expression (result) of MTP-PE associated with cancer and osteogenic sarcomas
6) Confidence 0.12 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893760 Disease Relevance 1.47 Pain Relevance 0.26
In patients with osteosarcoma and healthy adults, it is well documented that within hours after L-MTP-PE was given, plasma levels of proinflammatory molecules, such as TNF-?
Positive_regulation (documented) of Gene_expression (given) of MTP-PE in plasma associated with osteogenic sarcomas
7) Confidence 0.11 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893760 Disease Relevance 1.16 Pain Relevance 0.23

General Comments

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