INT18744

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.06
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nqo1) oxidoreductase activity (Nqo1) aging (Nqo1)
cytoplasm (Nqo1)
Anatomy Link Frequency
neurons 5
neuronal 1
parabrachial nucleus 1
Nqo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 26 100.00 Very High Very High Very High
gABA 18 100.00 Very High Very High Very High
Neuropeptide 11 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 1 100.00 Very High Very High Very High
Pain 5 99.70 Very High Very High Very High
medulla 6 99.04 Very High Very High Very High
Somatostatin 6 98.74 Very High Very High Very High
parabrachial 2 98.68 Very High Very High Very High
Central grey 5 98.32 Very High Very High Very High
projection neuron 4 90.20 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 5 98.32 Very High Very High Very High
Ganglion Cysts 7 96.16 Very High Very High Very High
Disease 4 92.56 High High
Pain 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar basic morphologies of the presumed interneurons and double staining of NADPH-diaphorase positive and somatostatin immunoreactive neurons suggest that the two neuropeptides and NADPH-diaphorase are extensively colocalized in the cultures, as in vivo.
Localization (colocalized) of NADPH-diaphorase in neurons associated with neuropeptide and somatostatin
1) Confidence 0.69 Published 1995 Journal Exp Brain Res Section Abstract Doc Link 7615039 Disease Relevance 0.24 Pain Relevance 0.47
We observed a considerable increase in Fos-positive neurons in many brain areas after noxious stimulation but only 15% of the Fos-positive neurons colocalized Nicotinamide Adenine Dinucleotide Phosphate Diaphorase (NADPH-d).
Localization (colocalized) of Diaphorase in neurons
2) Confidence 0.56 Published 1999 Journal Brain Res. Section Abstract Doc Link 10407110 Disease Relevance 0 Pain Relevance 0.07
To determine if grafted striatal neurons contain neurochemical markers similar to those in neurons in the caudate nucleus and to establish the morphological characteristics and relative frequency of labeled neurons in the grafts, the localization of immunoreactive GABA and leucine-enkephalin (ENK) and of NADPH-diaphorase (NADPH-d) activity was examined in fetal striatal grafts at the light and electron microscopic levels.
Spec (examined) Localization (localization) of NADPH-diaphorase in neurons associated with gaba and enkephalin
3) Confidence 0.34 Published 1988 Journal J. Comp. Neurol. Section Abstract Doc Link 2975675 Disease Relevance 0 Pain Relevance 0.47
Localization of immunoreactive GABA and enkephalin and NADPH-diaphorase-positive neurons in fetal striatal grafts in the quinolinic-acid-lesioned rat neostriatum.
Localization (Localization) of NADPH-diaphorase in neurons associated with gaba and enkephalin
4) Confidence 0.34 Published 1988 Journal J. Comp. Neurol. Section Title Doc Link 2975675 Disease Relevance 0 Pain Relevance 0.52
NADPH-diaphorase activity and its colocalization with transmitters and neuropeptides in the postganglionic neurons of the rat superior cervical ganglion.
Localization (colocalization) of NADPH-diaphorase in neurons associated with ganglion cysts and neuropeptide
5) Confidence 0.32 Published 1994 Journal Brain Res. Section Title Doc Link 7953706 Disease Relevance 0.55 Pain Relevance 0.41
After 16 months, the neostriatum was processed for the localization of immunoreactive GABA, calbindin, enkephalin and NADPH-diaphorase (-d) activity.
Localization (localization) of NADPH-diaphorase associated with gaba and enkephalin
6) Confidence 0.30 Published 1990 Journal Brain Res. Section Abstract Doc Link 1980852 Disease Relevance 0 Pain Relevance 0.54
Expression and colocalization of NADPH-diaphorase and Fos in the subnuclei of the parabrachial nucleus in rats following visceral noxious stimulation.
Localization (colocalization) of diaphorase in parabrachial nucleus associated with pain and parabrachial
7) Confidence 0.19 Published 2006 Journal Brain Res. Section Title Doc Link 16919249 Disease Relevance 0 Pain Relevance 0.37
Furthermore, neuronal NADPH-diaphorase (NADPH-d), which is considered as a marker of neuronal nitric oxide synthase (nNOS), has been localized in those same regions.
Localization (localized) of NADPH-diaphorase in neuronal associated with neuronal nitric oxide synthase
8) Confidence 0.01 Published 2002 Journal Life Sci. Section Abstract Doc Link 12377266 Disease Relevance 0.26 Pain Relevance 0.35

General Comments

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