INT187454

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 9.66
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptprc) plasma membrane (Ptprc)
Anatomy Link Frequency
microglial cells 2
Macrophages 1
superior 1
haematopoietic cells 1
Ptprc (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 183 98.68 Very High Very High Very High
Inflammation 811 94.84 High High
cytokine 391 94.04 High High
Inflammatory mediators 27 88.92 High High
Central nervous system 31 87.36 High High
Multiple sclerosis 32 82.96 Quite High
Hippocampus 78 81.20 Quite High
Inflammatory response 27 77.12 Quite High
ischemia 47 50.00 Quite Low
chemokine 21 50.00 Quite Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 182 99.76 Very High Very High Very High
Multiple Sclerosis 96 98.92 Very High Very High Very High
Disease 783 98.52 Very High Very High Very High
Cognitive Disorder 26 96.52 Very High Very High Very High
INFLAMMATION 893 94.84 High High
Apoptosis 89 94.56 High High
Injury 228 86.08 High High
Neurodegenerative Disease 52 85.92 High High
Cancer 238 85.36 High High
Demyelinating Disease 26 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, inhibition of either of these pathways augmented CD45RB cross-linking induced microglial phagocytosis of A?
CD45RB Binding (cross-linking) of
1) Confidence 0.38 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2366070 Disease Relevance 0.18 Pain Relevance 0.09
We have previously shown that cross-linking of CD45 using an agonistic CD45 antibody leads to inhibition of microglial activation induced by A?
CD45 Binding (cross) of
2) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.16 Pain Relevance 0.07
Our previous studies demonstrated CD45, a membrane-bound protein tyrosine phosphatase (PTP), opposed ?
CD45 Binding (opposed) of
3) Confidence 0.29 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2366070 Disease Relevance 0.30 Pain Relevance 0.03
Our data show that cross linking of CD45RB enhances microglial phagocytosis of A?
CD45RB Binding (cross) of
4) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.92 Pain Relevance 0.28
Data revealed cross-linking of CD45, particularly the CD45RB isoform, enhances microglial phagocytosis of A?
CD45 Binding (linking) of
5) Confidence 0.29 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2366070 Disease Relevance 0.23 Pain Relevance 0.09
Cross-linking of microglial CD45RB markedly suppresses p38 MAPK activation resulting from phen and A?
CD45RB Binding (linking) of
6) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.06 Pain Relevance 0
and IL-6 production after challenging LPS, and demonstrate the functionality of CD45RB cross-linking on p38 MAPK activity.


CD45RB Binding (linking) of
7) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.13 Pain Relevance 0.07
To examine whether cross-linking of CD45RB could inhibit formation of immunogenic MHC II-A?
CD45RB Spec (whether) Binding (cross) of
8) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.53 Pain Relevance 0.11
In summary, p38 MAPK is another novel signaling pathway, besides p44/42, in which CD45RB cross-linking negatively regulates microglial A?
CD45RB Neg (negatively) Binding (cross-linking) of
9) Confidence 0.28 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2366070 Disease Relevance 0.26 Pain Relevance 0.14
peptide, and also suggest cross-linking of CD45RB synergizes with SB203580 to inhibit phen and A?
CD45RB Binding (cross) of
10) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.05 Pain Relevance 0.03
and IL-6 production after challenging LPS, and demonstrate the functionality of CD45RB cross-linking on p38 MAPK activity.


CD45RB Binding (cross) of
11) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.13 Pain Relevance 0.07
In addition, we also observed that cross-linking of CD45RB has the same synergistic role with PD98059 in inhibiting phen and A?
CD45RB Binding (cross-linking) of
12) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.17 Pain Relevance 0.03
co-localization following the CD45RB cross-linking.
CD45RB Binding (linking) of
13) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.65 Pain Relevance 0.22
These data collectively showed that cross-linking CD45RB boosts microglial phagocytosis of A?
CD45RB Binding (cross-linking) of
14) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0 Pain Relevance 0
Finally, it was observed that cross-linking of CD45RB in the presence of A?
CD45RB Binding (linking) of
15) Confidence 0.28 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2366070 Disease Relevance 0.18 Pain Relevance 0.13
1–42 peptide, which was abrogated by cross-linking of CD45RB or SB203580, respectively (Fig. 4C, D).
CD45RB Binding (cross-linking) of
16) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0 Pain Relevance 0
These data led us to further investigate whether the observed effect of CD45 cross-linking on opposing microglial activation might be mediated via activation of the p38 MAPK modulation.
CD45 Binding (linking) of
17) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.06 Pain Relevance 0
To examine whether cross-linking of CD45RB could inhibit formation of immunogenic MHC II-A?
CD45RB Binding (linking) of
18) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.53 Pain Relevance 0.11
The cross-linking of CD45RB enhances microglial phagocytosis of A?
CD45RB Binding (linking) of
19) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.60 Pain Relevance 0.15
Finally, it was observed that cross-linking of CD45RB in the presence of A?
CD45RB Binding (cross) of
20) Confidence 0.28 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2366070 Disease Relevance 0.18 Pain Relevance 0.13

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