INT187456

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.51
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptprc) plasma membrane (Ptprc)
Anatomy Link Frequency
microglial cells 2
Ptprc (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 29 87.84 High High
Inflammation 24 80.08 Quite High
cytokine 3 16.68 Low Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 51 99.02 Very High Very High Very High
INFLAMMATION 24 80.08 Quite High
Adhesions 19 78.52 Quite High
Fever 2 58.08 Quite High
Acute-phase Reaction 1 47.32 Quite Low
Shock 1 34.80 Quite Low
Sepsis 1 33.08 Quite Low
Immunization 3 5.00 Very Low Very Low Very Low
Bordatella Infection 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As CD45 is upregulated on activated microglial cells, which reside in high numbers in CVOs [21], the increased number of CD45+ cells detected within the CVOs during EAE is most probably due to both the recruitment of circulating CD45+ immune cells from the periphery into these areas and additionally to the upregulation of CD45 on microglial cells residing within the CVOs.
Regulation (circulating) of CD45 Binding (immune cells) of in microglial cells associated with multiple sclerosis
1) Confidence 0.29 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.51 Pain Relevance 0.15

General Comments

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