INT187463

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.80
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptprc) plasma membrane (Ptprc)
Anatomy Link Frequency
microglial cells 6
granulocytes 3
Skeletal muscle 2
stem cells 2
neutrophils 2
Ptprc (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 58 97.00 Very High Very High Very High
cytokine 56 65.84 Quite High
Inflammation 69 65.68 Quite High
aspirin 42 57.88 Quite High
ischemia 71 50.00 Quite Low
anesthesia 7 39.52 Quite Low
cINOD 2 19.68 Low Low
cOX1 1 9.76 Low Low
COX2 1 9.40 Low Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 6 98.96 Very High Very High Very High
Colitis 1 96.56 Very High Very High Very High
Multiple Sclerosis 102 95.28 Very High Very High Very High
Targeted Disruption 4 95.12 Very High Very High Very High
Hypersensitivity 14 94.40 High High
Bacteremia 2 90.88 High High
Myocardial Infarction 23 88.96 High High
Osteoporosis 42 88.60 High High
Stroke 55 65.84 Quite High
INFLAMMATION 79 65.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of microglial cells by upregulated expression of CD45 and induction of Mac-1 therefore parallels the events observed within the CNS parenchyma protected by the BBB during EAE.
Positive_regulation (upregulated) of Gene_expression (expression) of CD45 in microglial cells associated with multiple sclerosis and central nervous system
1) Confidence 0.44 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.43 Pain Relevance 0.11
Activation of microglial cells by upregulated expression of CD45 and induction of Mac-1 therefore parallels the events observed within the CNS parenchyma protected by the BBB during EAE.
Positive_regulation (upregulated) of Gene_expression (expression) of CD45 in microglial cells associated with multiple sclerosis and central nervous system
2) Confidence 0.32 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.43 Pain Relevance 0.11
Indeed, MFI analysis showed that CD45 levels are upregulated in microglia 12–24 hours after pMCAO.
Positive_regulation (upregulated) of Gene_expression (levels) of CD45 in microglia
3) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.07 Pain Relevance 0.06
Microglia were separated from macrophages/granulocytes based on CD45 expression, with intermediate levels of CD45 (CD45dim) identifying CD11b+ parenchymal microglia, and high levels of CD45 (CD45high) identifying CD11b+ macrophage/granulocytes [28].
Positive_regulation (based) of Gene_expression (expression) of CD45 in granulocytes
4) Confidence 0.32 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.21 Pain Relevance 0
Skeletal muscle interstitium-derived CD34+/CD45?
Positive_regulation (derived) of Gene_expression (/) of CD45 in Skeletal muscle
5) Confidence 0.14 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2262151 Disease Relevance 0.34 Pain Relevance 0
Some degree of similarity exists between ERC and bone marrow derived mesenchymal stem cells, for example, expression of CD90, CD105 and lack of CD45 and CD34 [57].
Positive_regulation (derived) of Gene_expression (expression) of CD45 in stem cells
6) Confidence 0.11 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0 Pain Relevance 0.03
Microglia were separated from macrophages/granulocytes based on CD45 expression, with intermediate levels of CD45 (CD45dim) identifying CD11b+ parenchymal microglia, and high levels of CD45 (CD45high) identifying CD11b+ macrophage/granulocytes [28].
Positive_regulation (based) of in macrophage Gene_expression (expression) of CD45 in granulocytes
7) Confidence 0.11 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.21 Pain Relevance 0
On day 3, a marked increase in the percentage of total events that were CD45+, CD11b+, Ly6G+ neutrophils was seen in colonized versus uncolonized mice (Figure 2G, p<0.01).


Positive_regulation (increase) of Gene_expression (neutrophils) of CD45 in neutrophils
8) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.21 Pain Relevance 0.03
In contrast, transfer of the reciprocal CD4+CD45RB?
Positive_regulation (transfer) of Gene_expression (transfer) of CD45RB
9) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440798 Disease Relevance 0.92 Pain Relevance 0.08

General Comments

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