INT187465

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.71
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptprc) plasma membrane (Ptprc)
Anatomy Link Frequency
macrophages 1
granulocytes 1
leukocyte 1
oligodendrocytes 1
microglia 1
Ptprc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 91 96.52 Very High Very High Very High
Nav1.6 11 93.88 High High
imagery 32 56.44 Quite High
Inflammatory response 12 50.00 Quite Low
Central nervous system 30 13.44 Low Low
cytokine 49 5.00 Very Low Very Low Very Low
Multiple sclerosis 32 5.00 Very Low Very Low Very Low
Action potential 29 5.00 Very Low Very Low Very Low
Demyelination 26 5.00 Very Low Very Low Very Low
ischemia 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 28 99.92 Very High Very High Very High
Hypersensitivity 12 99.68 Very High Very High Very High
Cancer 51 99.08 Very High Very High Very High
Myocardial Infarction 70 98.84 Very High Very High Very High
Diabetes Mellitus 39 98.04 Very High Very High Very High
INFLAMMATION 103 96.52 Very High Very High Very High
Injury 141 95.76 Very High Very High Very High
Alzheimer's Dementia 10 85.48 High High
Multiple Sclerosis 268 83.04 Quite High
Cytomegalovirus Infection 14 82.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD45 and DiD signal colocalization, while present in all tumor tissues, was not uniformly distributed across all areas of the tumor specimens observed.
Localization (colocalization) of CD45 associated with cancer
1) Confidence 0.62 Published 2009 Journal J Transl Med Section Body Doc Link PMC2780997 Disease Relevance 0.80 Pain Relevance 0.03
CD45+ cells within all four CVOs were localized in close proximity to microvessels and were also found within the CVO parenchyma.
Localization (localized) of CD45 in parenchyma
2) Confidence 0.45 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.23 Pain Relevance 0
For analysis of microglia and macrophages/granulocytes, cells were gated on side scatter (SSC) versus CD11b, followed by forward scatter (FSC) versus CD11b, and FSC versus CD45.
Localization (followed) of CD45 in macrophages associated with hypersensitivity
3) Confidence 0.41 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.15 Pain Relevance 0
 ; 1:500, Chemicon) and anti-olig2 (1:500, Chemicon); mature oligodendrocytes: anti-glutathione S transferase-pi (GST-pi; 1:1000, Chemicon) and PLP-EGFP fluorescence; myelin: anti-myelin basic protein (1:1000, Chemicon); microglia/macrophage/monocyte: anti-CD45 (1:1000; PharMingen, La Jolla, CA); macrophages: Mac3 (1:500; BD Biosciences, San Diego, CA); T cells: anti-CD3 (1:1000, Abcam); nodal proteins: Caspr, Nav1.6, Kv1.2 (Alomone Labs, Jerusalem, Israel and Antibodies Inc, Davis, CA) were used.
Localization (fluorescence) of CD45 in oligodendrocytes associated with nav1.6
4) Confidence 0.40 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.31 Pain Relevance 0.09
Immuno labeling on different sections after MI confirmed the flow cytometric analysis, demonstrating co-localization of LacZ+ nuclei with Sca-1, CD31, and CD45 (Fig. 4b–d).
Localization (localization) of CD45 associated with myocardial infarction
5) Confidence 0.35 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.32 Pain Relevance 0
Not surprisingly, as shown in Figure 3, double labeling of GFP and Cd45 (a pan-leukocyte marker) revealed that although diabetic mice have similar numbers of inflammatory cells at day 0, they showed a fivefold increase in GFP+Cd45+ leukocytes in day 7 wounds and a twofold increase in day 14 wounds compared with nondiabetic controls (Fig. 3A, 3B).
Localization (labeling) of Cd45 in leukocyte associated with inflammation, diabetes mellitus and injury
6) Confidence 0.31 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 1.60 Pain Relevance 0.13
For analysis of microglia and macrophages/granulocytes, cells were gated on side scatter (SSC) versus CD11b, followed by forward scatter (FSC) versus CD11b, and FSC versus CD45.
Localization (followed) of CD45 in granulocytes associated with hypersensitivity
7) Confidence 0.14 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.15 Pain Relevance 0
For analysis of microglia and macrophages/granulocytes, cells were gated on side scatter (SSC) versus CD11b, followed by forward scatter (FSC) versus CD11b, and FSC versus CD45.
Localization (followed) of CD45 in microglia associated with hypersensitivity
8) Confidence 0.14 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.15 Pain Relevance 0

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