INT187472

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 2.68
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod1) aging (Sod1) peroxisome (Sod1)
intracellular (Sod1) protein complex (Sod1) cytoplasm (Sod1)
Anatomy Link Frequency
liver 4
muscle 4
muscle fibers 2
Sod1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 34 92.80 High High
cytokine 51 84.00 Quite High
tolerance 33 82.28 Quite High
Inflammatory mediators 11 61.16 Quite High
imagery 15 33.96 Quite Low
anesthesia 6 31.52 Quite Low
Hippocampus 2 19.92 Low Low
Spinal cord 19 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 57 100.00 Very High Very High Very High
Motor Neuron Diseases 93 98.64 Very High Very High Very High
Infection 3 98.08 Very High Very High Very High
Nerve Degeneration 6 95.96 Very High Very High Very High
Impaired Glucose Tolerance 30 95.40 Very High Very High Very High
INFLAMMATION 53 92.80 High High
Disease 56 87.96 High High
Adenovirus Infection 3 85.00 Quite High
Body Weight 15 81.28 Quite High
Stress 26 79.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the effect of SOD1 expression on ROS level in the liver, we stained each liver with the oxidation-dependent fluorescent dye DHE.
Spec (investigate) Regulation (effect) of Spec (investigate) Gene_expression (expression) of SOD1 in liver
1) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.08 Pain Relevance 0
In order to confirm this in the present study, we performed Western analysis of SOD1 expression in MG muscle from an B6.SOD1 donor that had been transplanted into a wild-type host 2 months earlier.
Regulation (analysis) of Gene_expression (expression) of SOD1 in muscle
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.06 Pain Relevance 0
There is at present no obvious explanation from the sites of the Loa, Cra1 and Swl mutations in the dynein gene to why two out of three of them affect the SOD1G93A phenotype, and the differences between these mice and the molecular mechanisms of each mutation clearly warrant closer examination.
Regulation (affect) of Gene_expression (phenotype) of SOD1G93A
3) Confidence 0.44 Published 2008 Journal Genome Biol Section Body Doc Link PMC2397497 Disease Relevance 0.29 Pain Relevance 0
The elevated expression of MnSOD, Cu/ZnSOD, reactive oxygen species (ROS), and reduction in glutathione, indicate altered redox balance upon LPS, A?
Regulation (indicate) of Gene_expression (expression) of Cu/ZnSOD
4) Confidence 0.44 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.37 Pain Relevance 0.26
By extension, this supports the conclusion that the properties of transplanted muscles have no effect on innervation status in either wild-type or B6.SOD1 transgenic mice.


Neg (no) Regulation (effect) of Gene_expression (transgenic mice) of SOD1 in muscles associated with targeted disruption
5) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842435 Disease Relevance 0.10 Pain Relevance 0
To elucidate the effect of the reduction of hepatic ROS on glucose metabolism, we investigated the effect of SOD1 overexpression in liver on blood glucose level in db/db mice.
Spec (investigated) Regulation (effect) of Gene_expression (overexpression) of SOD1 in liver
6) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.28 Pain Relevance 0.03
Here we examine whether this degeneration depends on expression of mutant SOD1 in muscle fibers.


Spec (whether) Regulation (depends) of Gene_expression (expression) of SOD1 in muscle fibers
7) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2842435 Disease Relevance 0.35 Pain Relevance 0
All 4 cases in this report were negative for changes in SOD1, ANG, TDP43, VAPB and FUS/TLS.
Regulation (negative) of Gene_expression (changes) of SOD1
8) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.89 Pain Relevance 0
To determine the tissue distribution of SOD1 expression, various tissues were isolated at 7 days after infection with the adenovirus.
Spec (determine) Regulation (distribution) of Gene_expression (expression) of SOD1 associated with infection
9) Confidence 0.23 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.26 Pain Relevance 0.08

General Comments

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