INT187495

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaa2) nucleus (Prkaa2) protein binding, bridging (Prkaa2)
protein complex (Prkaa2) response to stress (Prkaa2) cytoplasm (Prkaa2)
Prkaa2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 7 95.12 Very High Very High Very High
cytokine 44 72.08 Quite High
Inflammatory mediators 11 50.00 Quite Low
Inflammation 34 8.64 Low Low
ischemia 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 53 94.72 High High
Disease 36 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 15 5.00 Very Low Very Low Very Low
Stress 14 5.00 Very Low Very Low Very Low
Toxicity 7 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 4 5.00 Very Low Very Low Very Low
Neurological Disease 3 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inside the cell (in vivo) AICAR is converted to ZMP (an analog of AMP) which activates AMP kinase kinase (AMPKK) which in turn activates AMP kinase (AMPK) by phosphorylation on residues Thr 172 of the ?
Positive_regulation (activates) of Gene_expression (kinase) of AMPK
1) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.09 Pain Relevance 0.11

General Comments

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