INT187499

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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.28
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Fig4) Golgi apparatus (Fig4) endoplasmic reticulum (Fig4)
Anatomy Link Frequency
substantia nigra 2
bile 2
Fig4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 122 100.00 Very High Very High Very High
Ventral tegmentum 6 98.98 Very High Very High Very High
substance P 147 97.56 Very High Very High Very High
Substantia nigra 8 97.04 Very High Very High Very High
dorsal root ganglion 81 97.00 Very High Very High Very High
Hippocampus 51 93.92 High High
qutenza 20 91.96 High High
cOX1 2 91.52 High High
Kinase C 21 91.36 High High
Inflammation 41 90.40 High High
Disease Link Frequency Relevance Heat
Fistula 38 100.00 Very High Very High Very High
Ganglion Cysts 83 97.00 Very High Very High Very High
Disease 36 93.56 High High
Repression 8 93.36 High High
Amyloid Plaque 2 92.64 High High
INFLAMMATION 61 90.40 High High
Apoptosis 40 89.72 High High
Aggression 93 88.32 High High
Alzheimer's Dementia 15 84.56 Quite High
Nociception 27 69.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The substantia nigra showed a significant increase in BOLD signal over time (Fig 6), while the ventral tegmental area and its efferent connections showed an ostensible increase in the volume of activation (Fig 5).
Positive_regulation (increase) of Positive_regulation (increase) of Fig in substantia nigra associated with ventral tegmentum and substantia nigra
1) Confidence 0.21 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2601047 Disease Relevance 0.15 Pain Relevance 0.18
As expected, formaldehyde (>0.1 mM) induced an increase of cytosolic [Ca2+]i in a concentration-dependent manner (Fig. 4, G and H).
Positive_regulation (induced) of Positive_regulation (increase) of Fig
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858155 Disease Relevance 0.63 Pain Relevance 0.79
Because of the time lag between the activation of AKT and induction of SHP mRNA in the chronic bile fistula rat model (Fig. 6), we hypothesized that the activation of the insulin signaling pathway by TCA might be required for maximal activation of FXR and induction of SHP mRNA.
Positive_regulation (activation) of Positive_regulation (induction) of Fig in bile associated with bile and fistula
3) Confidence 0.16 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.25 Pain Relevance 0.12
Therefore, the activation of ERK1/2 (Fig. 1) by TCA may help stabilize SHP protein.
Positive_regulation (stabilize) of Positive_regulation (activation) of Fig
4) Confidence 0.16 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.09 Pain Relevance 0.09
Additionally, s.c. injection of either saline or bee venom significantly augmented the activation of ERK1 and ERK2 (Fig. 3A, Tables 1 and 2).
Positive_regulation (augmented) of Positive_regulation (activation) of Fig
5) Confidence 0.12 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.33 Pain Relevance 0.39
In addition, a single treatment of NP (9.51%), BPA (8.26%) or genistein (9.97%) induced a significant increase in gene expressions in this tissue (Fig. 2B), and there are 30 common genes by these EDs (Table 3).
Positive_regulation (induced) of Positive_regulation (increase) of Fig
6) Confidence 0.12 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
In addition, a single dose of E2 (4.1-fold) or DES (19.1-fold) induced a marked increase in Acrp30 (Fig. 3).
Positive_regulation (induced) of Positive_regulation (increase) of Fig
7) Confidence 0.12 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
Moreover, the de novo protein synthesis of COX-2 requires the activation of PKCs and MEK (Fig. 6B).
Positive_regulation (requires) of Positive_regulation (activation) of Fig
8) Confidence 0.10 Published 2007 Journal Mol Pain Section Body Doc Link PMC2235838 Disease Relevance 0.68 Pain Relevance 0.98
The MitoTracker staining suggests that the mitochondrial network is severely damaged after METH treatment (Fig. 3A, b1 and c1) and the number of cells with fragmented mitochondria increases with increasing concentrations of METH (Fig. 3C).
Positive_regulation (increases) of Positive_regulation (increasing) of Fig
9) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677674 Disease Relevance 0.64 Pain Relevance 0
peptide-induced activation of C/EBP (Fig. 9C-ii).


Positive_regulation (induced) of Positive_regulation (activation) of Fig
10) Confidence 0.04 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.51 Pain Relevance 0.14

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