INT187502

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.56
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Cebpg) nucleus (Cebpg) DNA binding (Cebpg)
transcription factor binding (Cebpg)
Cebpg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 35 98.58 Very High Very High Very High
Inflammation 35 90.08 High High
cytokine 45 63.84 Quite High
Inflammatory mediators 11 62.72 Quite High
Nerve growth factor 19 61.80 Quite High
Inflammatory response 7 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 37 93.24 High High
Amyloid Plaque 2 92.32 High High
INFLAMMATION 54 90.08 High High
Alzheimer's Dementia 15 84.16 Quite High
Neuroblastoma 3 56.24 Quite High
Cancer 4 45.92 Quite Low
Death 7 6.96 Low Low
Stress 15 5.00 Very Low Very Low Very Low
Apoptosis 9 5.00 Very Low Very Low Very Low
Toxicity 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, the transcriptional activity of C/EBP and Ngn2 might be downregulated in PC12 (WT-Akt) cells but upregulated in PC12 (DN-Akt) cells.
Positive_regulation (upregulated) of C/EBP
1) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.06 Pain Relevance 0.03
However, it has also been found that CS causes changes in gene as well as protein expression of transcription factors such as C/EBP-?
Positive_regulation (factors) of C/EBP associated with corticosteroid
2) Confidence 0.49 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.13
peptide-induced activation of C/EBP (Fig. 9C-ii).


Positive_regulation (activation) of C/EBP
3) Confidence 0.10 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.50 Pain Relevance 0.14

General Comments

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