INT187504

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 11
Disease Relevance 1.30
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaa2) nucleus (Prkaa2) protein binding, bridging (Prkaa2)
protein complex (Prkaa2) response to stress (Prkaa2) cytoplasm (Prkaa2)
Anatomy Link Frequency
hypothalamus 1
Prkaa2 (Rattus norvegicus)
Prkaa2 - R531G (2)
Pain Link Frequency Relevance Heat
Intracerebroventricular 15 97.44 Very High Very High Very High
Inflammatory response 7 94.28 High High
cytokine 54 72.08 Quite High
agonist 3 70.88 Quite High
Inflammatory mediators 11 50.00 Quite Low
Inflammation 34 7.80 Low Low
imagery 14 5.00 Very Low Very Low Very Low
qutenza 7 5.00 Very Low Very Low Very Low
Kinase C 7 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 3 95.68 Very High Very High Very High
Stress 168 94.56 High High
INFLAMMATION 53 93.88 High High
Obesity 117 92.96 High High
Immunization 7 85.44 High High
Diabetes Mellitus 7 82.08 Quite High
Appetite Loss 42 60.76 Quite High
Body Weight 15 18.32 Low Low
Disease 36 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inside the cell (in vivo) AICAR is converted to ZMP (an analog of AMP) which activates AMP kinase kinase (AMPKK) which in turn activates AMP kinase (AMPK) by phosphorylation on residues Thr 172 of the ?
Gene_expression (kinase) of AMPK
1) Confidence 0.65 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.09 Pain Relevance 0.11
AMPK, ACC, p70S6K and 4EBP1 protein expression (Figures 4b–e, lower panels).


Gene_expression (expression) of AMPK
2) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.07
In addition, we did not observe any normal stimulation of AMPK activity by AICAR in the hypothalamus of exercised rats, indicating that AMPK pathway is disrupted.
Gene_expression (pathway) of AMPK in hypothalamus
3) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.30 Pain Relevance 0
Consistent with food intake, AICAR increased AMPK threonine and ACC serine phosphorylation levels in the hypothalami of control rats, whilst in exercised animals, AICAR did not change AMPK/ACC phosphorylation status (Figures 3b and c).
Gene_expression (threonine) of AMPK
4) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.04
An important subsidiary finding of our study was that, although the expression levels of the WT and R531G mutants of AMPK in the stably transfected cells were identical, the RG mutant was about twice as active when measured in the absence of AMP, associated with a 2-fold higher basal Thr-172 phosphorylation (Figure 1).
Gene_expression (expression) of AMPK (R531G)
5) Confidence 0.22 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.23 Pain Relevance 0
We generated isogenic cell lines stably expressing AMPK complexes containing AMP-sensitive (wild-type, WT) or AMP-insensitive (R531G) ?
Gene_expression (expressing) of AMPK
6) Confidence 0.20 Published 2010 Journal Cell Metabolism Section Abstract Doc Link PMC2935965 Disease Relevance 0.05 Pain Relevance 0
Antibodies against AMPK-?
Gene_expression (Antibodies) of AMPK
7) Confidence 0.19 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.13 Pain Relevance 0
Antibodies against AMPK-?
Gene_expression (Antibodies) of AMPK
8) Confidence 0.19 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.13 Pain Relevance 0
Effects of Other AMPK-Activating Drugs
Gene_expression (Effects) of AMPK
9) Confidence 0.19 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.22 Pain Relevance 0
Antibodies against AMPK-?
Gene_expression (Antibodies) of AMPK
10) Confidence 0.19 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.14 Pain Relevance 0
After transfection, Flp-In HEK293 cells stably expressing either WT or R531G AMPK-?
Gene_expression (expressing) of AMPK (R531G)
11) Confidence 0.19 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0 Pain Relevance 0

General Comments

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