INT187505

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.24
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 1.21
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Fig4) Golgi apparatus (Fig4) endoplasmic reticulum (Fig4)
Anatomy Link Frequency
plasma 3
hepatocytes 2
bladder 2
keratinocyte 2
cortex 1
Fig4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 64 100.00 Very High Very High Very High
mu opioid receptor 97 99.84 Very High Very High Very High
Morphine 76 99.54 Very High Very High Very High
Kinase C 177 99.34 Very High Very High Very High
TRP channel 30 97.28 Very High Very High Very High
cerebral cortex 16 93.04 High High
Inflammation 78 92.96 High High
cytokine 67 89.44 High High
addiction 19 83.00 Quite High
narcan 67 77.32 Quite High
Disease Link Frequency Relevance Heat
Rupture 3 99.20 Very High Very High Very High
INFLAMMATION 102 92.96 High High
Stress 34 92.28 High High
Liver Disease 16 82.96 Quite High
Necrosis 10 82.32 Quite High
Cirrhosis 38 66.92 Quite High
Hepatic Encephalopathy 34 51.44 Quite High
Apoptosis 56 50.00 Quite Low
Alzheimer's Dementia 39 50.00 Quite Low
Ganglion Cysts 28 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immediately after PPD induction, the skin showed keratinocyte cytoplasmatic vacuolization (Fig. 1a), and membrane ruptures were also visible near the sites of vacuolization.
Positive_regulation (after) of Localization (vacuolization) of Fig in keratinocyte associated with rupture
1) Confidence 0.24 Published 2008 Journal Clinics Section Body Doc Link PMC2664235 Disease Relevance 0.18 Pain Relevance 0
0.042; see Fig. 4), as opposed to increased omissions (F(1,24)?
Positive_regulation (opposed) of Localization (see) of Fig
2) Confidence 0.14 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2080349 Disease Relevance 0 Pain Relevance 0
Two conditions may arise; either the stimulation by DR(N) may be linear, non-saturable (Fig. 3A) in nature for a given gene or dose of the drug (Eq. 11a) or it could be a saturable function (Fig. 3B) where the effect of the drug is limited by capacity-limited factors such as Smax and SC50 (Eq. 11b) as given by:
Positive_regulation (function) of Localization (saturable) of Fig
3) Confidence 0.12 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0
Two conditions may arise; either the stimulation by DR(N) may be linear, non-saturable (Fig. 3A) in nature for a given gene or dose of the drug (Eq. 11a) or it could be a saturable function (Fig. 3B) where the effect of the drug is limited by capacity-limited factors such as Smax and SC50 (Eq. 11b) as given by:
Positive_regulation (by) of Localization (saturable) of Fig
4) Confidence 0.12 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0
Time-dependent plots of both RMSD (Fig. 5B) and DSSP (Fig. 6B) indicate the S-MB simulation reaches equilibrium at ?
Positive_regulation (indicate) of Localization (plots) of Fig
5) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2805716 Disease Relevance 0 Pain Relevance 0
Time-dependent plots of both RMSD (Fig. 5B) and DSSP (Fig. 6B) indicate the S-MB simulation reaches equilibrium at ?
Positive_regulation (indicate) of Localization (plots) of Fig
6) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2805716 Disease Relevance 0 Pain Relevance 0
Fluorescence spectrometric analysis showed that NaAsO2 enhanced ROS generation in hepatocytes (Fig. 2C), (arrows indicate fluorescent dye, DCF uptake by hepatocytes) and that could be prevented by treatment with taurine.
Positive_regulation (enhanced) of Localization (generation) of Fig in hepatocytes
7) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0 Pain Relevance 0
After 4 weeks of portacaval anastomosis, these rats’ large increases in ammonia levels were observed in both plasma and cortex (Fig. 2D and E), while cholinergic markers were unaffected (Fig. 2A–D).
Positive_regulation (increases) of Localization (cortex) of Fig in plasma
8) Confidence 0.07 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.28 Pain Relevance 0.05
Our results show that treatment with intraluminal thrombin elicited MIF release from the rat bladder (Fig. 3B).
Positive_regulation (elicited) of Localization (release) of Fig in bladder
9) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0.07
level to increase from 2 ± 3 to 47 ± 8 pg/ml, and neither apocynin nor catalase significantly inhibited this release (Fig. 4).
Positive_regulation (increase) of Localization (release) of Fig
10) Confidence 0.06 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1574293 Disease Relevance 0.07 Pain Relevance 0.18
Addition of staurosporine and W7 together almost completely inhibited picrotoxin-stimulated eGFP-MARCKS translocation (Fig. 6e and f).
Positive_regulation (stimulated) of Localization (translocation) of Fig
11) Confidence 0.06 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.30
In spontaneously synaptically-active, pcDNA3-transfected cultures PKC inhibition had no effect on the R2/R1 ratio, implying that PKC does not play a role in agonist-stimulated M1 mACh receptor desensitization (Fig. 4a and e).
Positive_regulation (stimulated) of Localization (desensitization) of Fig associated with kinase c and agonist
12) Confidence 0.06 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.36
-induced ROS generation (Fig. 6) as well as nitric oxide release, very similar to that seen with other anti-oxidants such as NAC or Vitamin E [12,43].
Positive_regulation (induced) of Localization (release) of Fig
13) Confidence 0.04 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.40 Pain Relevance 0.23
Citral initially increased the agonist-evoked responses of TRPV1, TRPV2, and TRPV3 (Fig. 2A, B).
Positive_regulation (increased) of Localization (responses) of Fig associated with agonist
14) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.55
With 10 µM forskolin added to each condition for 5 min, the inhibition of cAMP after 60 min of morphine exposure was visible (Fig. 4B), illustrating that the increased cAMP is not merely a result of desensitization of MOR with this high dose of morphine.
Neg (not) Positive_regulation (increased) of Localization (desensitization) of Fig associated with mu opioid receptor and morphine
15) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.38
After 4 weeks of portacaval anastomosis, these rats’ large increases in ammonia levels were observed in both plasma and cortex (Fig. 2D and E), while cholinergic markers were unaffected (Fig. 2A–D).
Positive_regulation (increases) of in cortex Localization (cortex) of Fig in plasma
16) Confidence 0.02 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 0.28 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox