INT187513

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2009
Negated 2
Speculated 1
Reported most in Body
Documents 5
Total Number 34
Disease Relevance 34.09
Pain Relevance 18.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pla2g4a) aging (Pla2g4a) Golgi apparatus (Pla2g4a)
endoplasmic reticulum (Pla2g4a) cytoplasmic membrane-bounded vesicle (Pla2g4a) nucleus (Pla2g4a)
Anatomy Link Frequency
neurons 11
nerve 6
plasma 2
spinal nerve 2
liver 1
Pla2g4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 2310 99.84 Very High Very High Very High
Neuropathic pain 390 99.76 Very High Very High Very High
Peripheral nerve injury 300 99.68 Very High Very High Very High
Root ganglion neuron 30 99.56 Very High Very High Very High
Spinal cord 180 99.00 Very High Very High Very High
Brush evoked pain 570 97.60 Very High Very High Very High
Pain 240 96.32 Very High Very High Very High
Sciatic nerve 30 94.88 High High
antagonist 90 93.84 High High
Eae 120 91.32 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 2340 99.84 Very High Very High Very High
Nervous System Injury 1320 99.82 Very High Very High Very High
Neuropathic Pain 1050 99.76 Very High Very High Very High
Injury 152 98.16 Very High Very High Very High
Fever 177 97.70 Very High Very High Very High
Disease 36 97.16 Very High Very High Very High
Pain 270 96.32 Very High Very High Very High
Inflammatory Pain 30 90.04 High High
Cognitive Disorder 2 88.72 High High
INFLAMMATION 134 85.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among protein kinases involved in cPLA2 activation described above, MAPKs and CaMKII are expressed in DRG neurons and have important roles in pain signaling.
Positive_regulation (activation) of cPLA2 in neurons associated with pain and dorsal root ganglion
1) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.72 Pain Relevance 0.43
These results indicate that p38 and ERK are not involved in nerve injury-induced cPLA2 activation in DRG neurons.


Positive_regulation (activation) of cPLA2 in nerve associated with dorsal root ganglion and nervous system injury
2) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.14 Pain Relevance 0.44
To further test whether the inhibition of CaMKII activation affects nerve injury-induced cPLA2 activation, we injected a CaMKII inhibitor, KN-93, and a negative control for KN-93, KN-92, into nerve-injured rats.
Positive_regulation (activation) of cPLA2 in nerve associated with nervous system injury
3) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.10 Pain Relevance 0.41
A CaMKII inhibitor suppresses nerve injury-induced cPLA2 activation
Positive_regulation (activation) of cPLA2 in nerve associated with nervous system injury
4) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.15 Pain Relevance 0.41
Applying ATP caused an increase in the levels of both phosphorylated cPLA2 and CaMKII in the vicinity of the plasma membrane, and physical association of these two proteins in primary cultured DRG neurons.
Positive_regulation (increase) of cPLA2 in plasma associated with dorsal root ganglion
5) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.26 Pain Relevance 0.98
In particular, ERK and cPLA2 are activated in different types of cells in the injured DRG: ERK phosphorylation was seen predominantly in satellite glial cells, while activation of cPLA2 is observed mainly in medium-to-large-diameter DRG neurons [2], which supports our hypothesis.
Positive_regulation (activation) of cPLA2 in neurons associated with dorsal root ganglion
6) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.23 Pain Relevance 0.77
Thus, it raises the possibility that peripheral nerve injury may induce the activation of cPLA2 via the phosphorylation of MAPKs and CaMKII in primary afferent neurons, but their roles remain to be determined.
Positive_regulation (activation) of cPLA2 in peripheral nerve associated with nervous system injury and peripheral nerve injury
7) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.92 Pain Relevance 0.45
In particular, ERK and cPLA2 are activated in different types of cells in the injured DRG: ERK phosphorylation was seen predominantly in satellite glial cells, while activation of cPLA2 is observed mainly in medium-to-large-diameter DRG neurons [2], which supports our hypothesis.
Positive_regulation (activated) of cPLA2 in neurons associated with dorsal root ganglion
8) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.30 Pain Relevance 0.82
Given the present data showing that cPLA2 and CaMKII are activated via stimulation of P2X3R/P2X2+3R in DRG neurons, this work indicates that P2X3R/P2X2+3R-dependent activation of cPLA2 and CaMKII is enhanced under pathological conditions, such as neuropathic pain.


Positive_regulation (activated) of cPLA2 in neurons associated with dorsal root ganglion and neuropathic pain
9) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.50 Pain Relevance 0.77
Activation of P2X3 and P2X2+3 receptors (P2X3R/P2X2+3R), ionotropic ATP receptor subtypes, is involved in nerve injury-induced cPLA2 activation in DRG neurons [2]; however, the mechanism underlying cPLA2 activation via P2X3R/P2X2+3R remains to be elucidated.
Positive_regulation (activation) of cPLA2 in neurons associated with dorsal root ganglion and nervous system injury
10) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.93 Pain Relevance 0.54
We have previously shown that spinal nerve injury induces the activation of cytosolic phospholipase A2 (cPLA2) in injured dorsal root ganglion (DRG) neurons that contribute to tactile allodynia.
Positive_regulation (activation) of cPLA2 in neurons associated with ganglion cysts, brush evoked pain, dorsal root ganglion and nervous system injury
11) Confidence 0.42 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2684092 Disease Relevance 1.28 Pain Relevance 0.80
The increases in the levels of p-cPLA2 and p-CaMKII induced by ??
Positive_regulation (increases) of p-cPLA2
12) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.62 Pain Relevance 0.41
These results indicate that P2X3R/P2X2+3R and VDCCs have important roles in cPLA2 and CaMKII activation, and that p-cPLA2 is translocated to the plasma membranes of DRG neurons as a result of its interaction with p-CaMKII.


Positive_regulation (activation) of cPLA2 in neurons associated with dorsal root ganglion
13) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.80 Pain Relevance 0.52
The activation of cPLA2 is regulated by phosphorylation of serine residues in addition to a rise in intracellular Ca2+ concentration [10].
Positive_regulation (activation) of cPLA2
14) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.81 Pain Relevance 0.50
However, on day 7, the levels of phosphorylated cPLA2 (p-cPLA2) in the ipsilateral DRGs of U0126- and SB203580-treated rats were not changed compared with that in vehicle-treated rats.
Neg (not) Positive_regulation (changed) of p-cPLA2
15) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.05 Pain Relevance 0.43
The increases in the levels of p-cPLA2 and p-CaMKII induced by ??
Positive_regulation (induced) of p-cPLA2
16) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.62 Pain Relevance 0.41
Subsequently, activated CaMKII would phosphorylate cPLA2 and be translocated to the plasma membrane by interacting physically with activated cPLA2.
Positive_regulation (activated) of cPLA2 in plasma
17) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 0.62 Pain Relevance 0.70
Activated cPLA2 hydrolyzes the sn-2 position of glycerophospholipids to release arachidonic acid and lysophospholipid, and subsequently generates lipid mediators such as prostaglandins, leukotrienes, platelet-activating factor and lysophosphatidic acid.
Positive_regulation (Activated) of cPLA2 in platelet
18) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.08 Pain Relevance 0.68
However, on day 7, the levels of phosphorylated cPLA2 (p-cPLA2) in the ipsilateral DRGs of U0126- and SB203580-treated rats were not changed compared with that in vehicle-treated rats.
Neg (not) Positive_regulation (changed) of cPLA2
19) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2684092 Disease Relevance 1.10 Pain Relevance 0.44
These results suggest that CaMKII, but not MAPKs, has an important role in cPLA2 activation following peripheral nerve injury, probably through P2X3R/P2X2+3R and VDCCs in primary afferent neurons.



Positive_regulation (activation) of cPLA2 in afferent neurons associated with nervous system injury and peripheral nerve injury
20) Confidence 0.42 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2684092 Disease Relevance 0.93 Pain Relevance 0.48

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