INT187518

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.99
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkag1) cytosol (ATIC) mitochondrion (ATIC)
small molecule metabolic process (ATIC) nucleus (Prkag1) protein complex (Prkag1)
ATIC (Homo sapiens)
Prkag1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 34 88.40 High High
cytokine 44 77.28 Quite High
Inflammatory mediators 11 53.76 Quite High
Inflammatory response 7 30.16 Quite Low
ischemia 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 53 88.40 High High
Stress 14 87.80 High High
Disease 36 79.04 Quite High
Neurological Disease 3 72.80 Quite High
Drug Induced Neurotoxicity 4 60.96 Quite High
Death 6 59.28 Quite High
Apoptosis 3 58.48 Quite High
Alzheimer's Dementia 15 5.00 Very Low Very Low Very Low
Toxicity 7 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AICAR is also reported to activate AMPK in the cell following its conversion to ZMP (a non-degradable AMP analog) and thus mimics the activity of AMP for activation of AMPK [18].
Positive_regulation (following) of AICAR Positive_regulation (activate) of AMPK
1) Confidence 0.01 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.99 Pain Relevance 0.25

General Comments

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