INT187521

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.07
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkag1) cytosol (ATIC) mitochondrion (ATIC)
small molecule metabolic process (ATIC) nucleus (Prkag1) protein complex (Prkag1)
Anatomy Link Frequency
bands 1
ATIC (Homo sapiens)
Prkag1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 14 87.92 High High
cytokine 88 87.44 High High
Inflammation 68 86.64 High High
Inflammatory mediators 22 53.76 Quite High
ischemia 6 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 28 87.80 High High
INFLAMMATION 106 87.52 High High
Disease 72 79.04 Quite High
Neurological Disease 6 72.80 Quite High
Drug Induced Neurotoxicity 8 60.96 Quite High
Death 12 59.28 Quite High
Apoptosis 6 58.48 Quite High
Alzheimer's Dementia 30 5.00 Very Low Very Low Very Low
Toxicity 14 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AICAR is also reported to activate AMPK in the cell following its conversion to ZMP (a non-degradable AMP analog) and thus mimics the activity of AMP for activation of AMPK [18].
AICAR Positive_regulation (activate) of AMPK
1) Confidence 0.01 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.98 Pain Relevance 0.25
AICAR treatment of glial cells activated AMPK as evident from the enhanced intensities of the phospho-specific protein bands of this AMPK at Ser-108 and Thr-172 (Fig. 8B and 8C).
AICAR Positive_regulation (activated) of AMPK in bands
2) Confidence 0.01 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.09 Pain Relevance 0.12

General Comments

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