INT187522

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.46
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ATIC, Nos2) mitochondrion (ATIC) aging (Nos2)
small molecule metabolic process (ATIC) peroxisome (Nos2) intracellular (Nos2)
Anatomy Link Frequency
glial cells 2
ATIC (Homo sapiens)
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 88 100.00 Very High Very High Very High
Inflammation 68 100.00 Very High Very High Very High
Inflammatory response 14 90.76 High High
Inflammatory mediators 22 89.52 High High
adenocard 2 57.56 Quite High
Multiple sclerosis 2 44.80 Quite Low
ischemia 6 36.48 Quite Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 106 100.00 Very High Very High Very High
Stress 28 76.32 Quite High
Insulin Resistance 2 72.48 Quite High
Disease 72 67.56 Quite High
Toxicity 14 65.44 Quite High
Neurological Disease 6 61.32 Quite High
Drug Induced Neurotoxicity 8 49.48 Quite Low
Body Weight 6 48.52 Quite Low
Death 12 47.80 Quite Low
Apoptosis 6 47.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
in glia reversed the AICAR-mediated inhibition of iNOS gene expression in response to LPS treatment [19].
AICAR Negative_regulation (inhibition) of Gene_expression (expression) of iNOS
1) Confidence 0.02 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.60 Pain Relevance 0.35
AICAR was found to inhibit expression of pro-inflammatory cytokines and of iNOS in glial cells and in macrophages in cell culture as well as in rats treated with a sublethal dose of LPS [19] by attenuating NF?
AICAR Negative_regulation (inhibit) of Gene_expression (expression) of iNOS in glial cells associated with inflammation and cytokine
2) Confidence 0.02 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.86 Pain Relevance 0.35

General Comments

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