INT18755

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2010
Negated 2
Speculated 5
Reported most in Abstract
Documents 79
Total Number 85
Disease Relevance 60.00
Pain Relevance 92.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
RVM 47
lamina 6
dorsal horn 4
neurons 4
tail 2
Rvm (Mus musculus)
Pain Link Frequency Relevance Heat
Rostral ventromedial medulla 2253 100.00 Very High Very High Very High
Central grey 127 100.00 Very High Very High Very High
medulla 121 100.00 Very High Very High Very High
Periaqueductal grey 88 100.00 Very High Very High Very High
Serotonin 73 100.00 Very High Very High Very High
Rostroventromedial medulla 72 100.00 Very High Very High Very High
Antinociceptive 62 100.00 Very High Very High Very High
nMDA receptor 54 100.00 Very High Very High Very High
Glutamate 49 100.00 Very High Very High Very High
lidocaine 41 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 303 100.00 Very High Very High Very High
Nervous System Injury 1282 99.98 Very High Very High Very High
Neuropathic Pain 561 99.98 Very High Very High Very High
INFLAMMATION 392 99.98 Very High Very High Very High
Arthritis 14 99.84 Very High Very High Very High
Hyperalgesia 398 99.82 Very High Very High Very High
Injury 149 99.82 Very High Very High Very High
Stress 16 99.82 Very High Very High Very High
Hypoalagesia 1 99.60 Very High Very High Very High
Inflammatory Pain 74 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we investigated the possibility that glial activation in the RVM could promote descending facilitation from the RVM in states of inflammatory pain.
Positive_regulation (activation) of RVM in RVM associated with rostroventromedial medulla, ipn, ascending facilitation and glial activation
1) Confidence 0.60 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19614984 Disease Relevance 0.79 Pain Relevance 1.05
Inflammation-induced microglial and astrocytic activation in the RVM were attenuated by RVM microinjection of the glial inhibitors.
Positive_regulation (activation) of RVM in RVM associated with rostroventromedial medulla and inflammation
2) Confidence 0.53 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19614984 Disease Relevance 0.94 Pain Relevance 1.40
These findings suggest that the activation of NK-1 receptors in the RVM contributes to the hyperalgesia produced by capsaicin.
Positive_regulation (activation) of RVM in RVM associated with hyperalgesia, qutenza and rostral ventromedial medulla
3) Confidence 0.44 Published 2008 Journal Pain Section Abstract Doc Link 18407414 Disease Relevance 0.40 Pain Relevance 1.38
To the best of our knowledge, these results show for the first time that the initial response to nerve damage requires facilitation from the RVM.
Positive_regulation (requires) of RVM in nerve associated with nervous system injury and rostral ventromedial medulla
4) Confidence 0.44 Published 2008 Journal J Pain Section Abstract Doc Link 18343729 Disease Relevance 1.11 Pain Relevance 1.03
Similar to PGE(2), an intraplantar injection of capsaicin (0.1 mg) produced a robust thermal hypersensitivity that was paralleled by a 3-fold increase in levels of 5-HT in the RVM.
Positive_regulation (increase) of RVM in RVM associated with qutenza, hypersensitivity and rostral ventromedial medulla
5) Confidence 0.40 Published 2006 Journal Brain Res. Section Abstract Doc Link 16730668 Disease Relevance 0.70 Pain Relevance 1.20
Activation of glutamatergic receptors in the RVM replicated the effects of electrical stimulation.
Positive_regulation (Activation) of RVM in RVM
6) Confidence 0.40 Published 2002 Journal Gastroenterology Section Body Doc Link 11910353 Disease Relevance 0.08 Pain Relevance 0
In vivo microdialysis studies in the same animals revealed that this behavioral response correlated with a greater than 2-fold increase (230%) in extracellular serotonin (5-HT) levels in the RVM.
Positive_regulation (increase) of RVM in RVM associated with serotonin and rostral ventromedial medulla
7) Confidence 0.40 Published 2006 Journal Brain Res. Section Abstract Doc Link 16730668 Disease Relevance 0.63 Pain Relevance 1.02
Moreover, the activation of RVM ON-cells produced by a noxious stimulus is sufficient to enhance some nocifensor reflexes, whereas neural structures other than the RVM appear to mediate the antinociceptive effects produced by a prolonged noxious stimulus.
Positive_regulation (activation) of RVM in RVM associated with antinociceptive and rostral ventromedial medulla
8) Confidence 0.40 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7807201 Disease Relevance 0.14 Pain Relevance 0.72
If off-cells are made to fire continuously by direct electrical stimulation of the RVM, the tail-flick reflex does not occur.
Positive_regulation (stimulation) of RVM in tail associated with tail-flick and rostral ventromedial medulla
9) Confidence 0.40 Published 1983 Journal Nature Section Abstract Doc Link 6656868 Disease Relevance 0.08 Pain Relevance 1.44
There is an initial decrease and a subsequent increase in the excitability of neurons in the RVM involving facilitation and inhibition.
Positive_regulation (increase) of RVM in neurons
10) Confidence 0.40 Published 2004 Journal Suppl Clin Neurophysiol Section Abstract Doc Link 16106600 Disease Relevance 0.56 Pain Relevance 0.39
The data show that inflammatory pain is associated with glial activation in the RVM that probably participates in driving descending pain facilitation.
Spec (probably) Positive_regulation (activation) of RVM in RVM associated with pain, rostroventromedial medulla, ipn and glial activation
11) Confidence 0.38 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19614984 Disease Relevance 0.99 Pain Relevance 1.35
Additionally, the data suggest that descending facilitation involves activation of NMDA receptors and production NO* in the RVM, whereas inhibition involves activation of non-NMDA receptors in the RVM.
Positive_regulation (activation) of RVM in RVM associated with nmda receptor, ascending facilitation and rostral ventromedial medulla
12) Confidence 0.36 Published 1999 Journal Pain Section Abstract Doc Link 10353492 Disease Relevance 0.53 Pain Relevance 1.25
A role for nitric oxide synthase in the RVM in mustard oil hyperalgesia was further demonstrated by a significant increase in the number of NADPH-d labeled cells in the RVM at the time of maximal hyperalgesia.
Positive_regulation (increase) of RVM in RVM associated with hyperalgesia and rostral ventromedial medulla
13) Confidence 0.36 Published 1999 Journal Pain Section Abstract Doc Link 10353492 Disease Relevance 0.72 Pain Relevance 1.44
Activation of cell bodies in the RVM by glutamate microinjection reproduced the biphasic modulatory effects of electrical stimulation.
Positive_regulation (Activation) of RVM in RVM associated with glutamate and rostral ventromedial medulla
14) Confidence 0.36 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9307109 Disease Relevance 0.22 Pain Relevance 0.78
Carrageenan-induced inflammation increased immunolabeling for microglia and astrocytes in the RVM, as well as for phosphorylated p38 MAPK.
Positive_regulation (increased) of RVM in microglia associated with rostroventromedial medulla and inflammation
15) Confidence 0.35 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19614984 Disease Relevance 0.99 Pain Relevance 1.41
One mechanism which may mediate such pain facilitation is through the increased activity of CCK in the RVM.
Positive_regulation (increased) of RVM in RVM associated with pain and rostral ventromedial medulla
16) Confidence 0.35 Published 2003 Journal Life Sci. Section Abstract Doc Link 12801599 Disease Relevance 0.86 Pain Relevance 2.39
The spontaneous activity of presumably pronociceptive ON-cells of the RVM and that of antinociceptive OFF-cells was increased in arthritis.
Positive_regulation (increased) of RVM in RVM associated with rostroventromedial medulla, antinociceptive and arthritis
17) Confidence 0.35 Published 2008 Journal Brain Res. Section Abstract Doc Link 18242585 Disease Relevance 0.99 Pain Relevance 1.48
Since glutamate and excitatory amino acid (EAA) receptors are also active in the RVM, the present study evaluated whether either competitive (AP7) or non-competitive (MK-801) N-methyl-D-aspartate (NMDA) antagonists or a kainate/AMPA (CNQX) antagonist microinjected into the RVM altered morphine (2.5 micrograms) analgesia elicited from the PAG as measured by the tail-flick and jump tests.
Positive_regulation (active) of RVM in tail associated with glutamate, antagonist, tail-flick, central grey, analgesia, morphine, rostral ventromedial medulla and excitatory amino acid
18) Confidence 0.33 Published 1996 Journal Pain Section Abstract Doc Link 8783320 Disease Relevance 0.36 Pain Relevance 1.98
Hence, low-frequency and high-frequency TENS produces antihyperalgesia by activation of mu- and delta-opioid receptors, respectively, in the RVM.
Positive_regulation (activation) of RVM in RVM associated with medulla, delta opioid receptors and transcutaneous nerve stimulation
19) Confidence 0.33 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11408550 Disease Relevance 0.11 Pain Relevance 1.50
The selective attenuation of allodynia induced by lidocaine in the RVM and the PAG is independent of opiate receptors, and it can not be explained by a systemic spread of the drug.
Positive_regulation (induced) of RVM in RVM associated with rostroventromedial medulla, allodynia, opiate, central grey and lidocaine
20) Confidence 0.32 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8945744 Disease Relevance 1.06 Pain Relevance 2.33

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