INT187571

Context Info Confidence 0.00 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.46 Pain Relevance 0

nucleoplasm (FANCB) extracellular space (Pf4) extracellular region (Pf4) nucleus (FANCB) protein complex assembly (Pf4) molecular_function (Pf4)

Anatomy Link Frequency platelet 1 FANCB (Homo sapiens) Pf4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cva 6 5.00 withdrawal 1 5.00 Serotonin 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Heparin-induced Thrombocytopenia 75 99.10 Thrombocytopenia 17 69.84 Thrombosis 17 24.28 Thrombosis Related Under Development 5 5.00 Syndrome 4 5.00 Necrosis 2 5.00 Pulmonary Embolism 2 5.00 Cv General 3 Under Development 2 5.00 Amputation 2 5.00 Death 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

In fact, patients who develop HIT produce an IgG antibody against the heparin-PF4 complex, which binds to the complex on platelet surface through the Fab region [20].

Fab Binding (binds) of PF4 in platelet associated with heparin-induced thrombocytopenia

1) Confidence 0.00 Published 2005 Journal Thromb J Section Body Doc Link PMC1262784 Disease Relevance 0.46 Pain Relevance 0

General Comments

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