INT187577

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Kcnk6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 9 99.96 Very High Very High Very High
qutenza 110 93.76 High High
Potency 15 27.04 Quite Low
antagonist 13 24.40 Low Low
tissue acidosis 3 5.00 Very Low Very Low Very Low
IPN 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
TRP channel 1 5.00 Very Low Very Low Very Low
ASIC 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 1 93.36 High High
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Inflammatory Pain 3 5.00 Very Low Very Low Very Low
Acidosis 3 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent publication has shown that acidic conditions, in combination with agonists, lock the TWIK-2 channel in an open conformation that persists even after the pH is neutralized [19].
Negative_regulation (lock) of TWIK-2 associated with agonist
1) Confidence 0.12 Published 2005 Journal Mol Pain Section Body Doc Link PMC1266034 Disease Relevance 0.09 Pain Relevance 0.92

General Comments

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