INT187589

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.93
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome segregation (Brca1) intracellular (Brca1) enzyme binding (Brca1)
DNA binding (Brca1) protein complex (Brca1) ligase activity (Brca1)
Anatomy Link Frequency
MCF-7 2
Brca1 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 12 54.24 Quite High
Immobilon 4 38.48 Quite Low
agonist 9 22.56 Low Low
addiction 12 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 30 99.60 Very High Very High Very High
Ovarian Cancer 17 93.08 High High
Cancer 16 89.36 High High
Genetic Predisposition To Disease 1 85.88 High High
Prostate Cancer 80 71.80 Quite High
Carcinoma 1 69.60 Quite High
Benign Tumor 1 66.60 Quite High
Malignant Neoplastic Disease 5 65.40 Quite High
Granulosa Cell Tumor 1 60.32 Quite High
Endometroid Carcinoma 1 33.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, the expression of MAK, CBP, and BRCA1 was increased more in LNCaP-ARhi than in LNCaP-pcDNA3.1, and, at least, a 10-fold sensitization was observed.
Positive_regulation (increased) of Gene_expression (expression) of BRCA1
1) Confidence 0.55 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0.14 Pain Relevance 0.03
However, induction of expression in lower concentrations of DHT in LNCaP-ARhi compared to LNCaP-pcDNA3.1 was found in MAK, CBP, AIB1, and BRCA1.
Positive_regulation (induction) of Gene_expression (found) of BRCA1
2) Confidence 0.40 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0 Pain Relevance 0
Next, we screened expression of SRC1, TIF2, PIAS1, PIASx, ARIP4, BRCA1, ?
Positive_regulation (screened) of Gene_expression (expression) of BRCA1
3) Confidence 0.37 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0 Pain Relevance 0
Our data shows an androgen-mediated induction of the expression of BRCA1.
Positive_regulation (induction) of Gene_expression (expression) of BRCA1
4) Confidence 0.37 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0.62 Pain Relevance 0
increase levels of BRCA1 in MCF-7 breast cancer cells [134].
Positive_regulation (increase) of Gene_expression (levels) of BRCA1 in MCF-7 associated with breast cancer
5) Confidence 0.14 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 1.17 Pain Relevance 0

General Comments

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