INT18759

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 22
Total Number 24
Disease Relevance 5.02
Pain Relevance 6.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2E1) oxidoreductase activity (CYP2E1) endoplasmic reticulum (CYP2E1)
enzyme binding (CYP2E1)
Anatomy Link Frequency
blood 2
hepatocytes 2
CYP2E1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 57 99.82 Very High Very High Very High
Paracetamol 120 99.68 Very High Very High Very High
Inflammation 144 82.60 Quite High
cytokine 63 62.16 Quite High
COX2 3 24.40 Low Low
tolerance 6 11.20 Low Low
fibrosis 57 5.00 Very Low Very Low Very Low
Inflammatory response 33 5.00 Very Low Very Low Very Low
chemokine 18 5.00 Very Low Very Low Very Low
Bile 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 7 99.40 Very High Very High Very High
Apoptosis 183 99.36 Very High Very High Very High
Nasopharynx Cancer 103 99.32 Very High Very High Very High
Stress 325 98.04 Very High Very High Very High
Infection 31 97.36 Very High Very High Very High
Toxicity 30 96.96 Very High Very High Very High
Respiratory Syncytial Virus 1 93.56 High High
Avian Sarcoma 1 93.12 High High
Cirrhosis 135 90.88 High High
Necrosis 44 89.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Various factors, including exposure to certain xenobiotics, can induce CYP2E1 expression and thereby result in an increase in its metabolic activity.
Positive_regulation (induce) of Gene_expression (expression) of CYP2E1
1) Confidence 0.70 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0 Pain Relevance 0
Toluene induces expression of cytochrome P450 2E1 (CYP2E1), an enzyme involved in its own metabolism and that of other protoxicants, including some procarcinogens.
Positive_regulation (induces) of Gene_expression (expression) of CYP2E1
2) Confidence 0.70 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1440770 Disease Relevance 0 Pain Relevance 0
To study the biochemical and toxicological properties of cytochrome P450 2E1 (CYP2E1), an adenovirus containing human CYP2E1 cDNA (Ad-CYP2E1) was constructed and was shown to successfully mediate the overexpression of CYP2E1 in HepG2 cells.
Positive_regulation (mediate) of Gene_expression (overexpression) of CYP2E1
3) Confidence 0.70 Published 2004 Journal Mol. Cell. Biochem. Section Abstract Doc Link 15532721 Disease Relevance 0.36 Pain Relevance 0.53
Apoptosis induced by APAP in HepG2 cells overexpressing CYP2E1 was caspase dependent and could be inhibited by the pan-caspase inhibitor Z-VAD-fmk.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of CYP2E1 associated with paracetamol and apoptosis
4) Confidence 0.70 Published 2004 Journal Mol. Cell. Biochem. Section Abstract Doc Link 15532721 Disease Relevance 0.51 Pain Relevance 0.84
These results demonstrate that adenovirus-mediated overexpression of human CYP2E1 activates APAP to reactive metabolites which damage mitochondria, form protein adducts, and result in toxicity to HepG2 cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CYP2E1 associated with toxicity and paracetamol
5) Confidence 0.70 Published 2004 Journal Mol. Cell. Biochem. Section Abstract Doc Link 15532721 Disease Relevance 0.46 Pain Relevance 0.85
Adenovirus mediated overexpression of CYP2E1 increases sensitivity of HepG2 cells to acetaminophen induced cytotoxicity.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CYP2E1 associated with paracetamol
6) Confidence 0.70 Published 2004 Journal Mol. Cell. Biochem. Section Title Doc Link 15532721 Disease Relevance 0.37 Pain Relevance 0.67
Clones were selected for resistance to the neomycin analog, G418, and then screened for expression of the CYP2E1 isozyme by testing for 6-hydroxylation of chlorzoxazone, a specific substrate for CYP2E1.
Positive_regulation (screened) of Gene_expression (expression) of CYP2E1
7) Confidence 0.69 Published 1993 Journal Eur. J. Biochem. Section Abstract Doc Link 8391436 Disease Relevance 0.19 Pain Relevance 0.04
Toluene induces expression of cytochrome P450 2E1 (CYP2E1), an enzyme involved in its own metabolism and that of other protoxicants, including some procarcinogens.
Positive_regulation (induces) of Gene_expression (expression) of cytochrome P450 2E1
8) Confidence 0.50 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1440770 Disease Relevance 0 Pain Relevance 0
This dissociation may be due to the capacity of toluene to induce CYP2E1 mRNA expression, whereas hippuric acid reflects toluene disposition.
Positive_regulation (induce) of Gene_expression (expression) of CYP2E1 mRNA
9) Confidence 0.50 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0 Pain Relevance 0
Acetaminophen metabolism and cytotoxicity in PC12 cells transfected with cytochrome P4502E1.
Positive_regulation (transfected) of Gene_expression (transfected) of cytochrome P4502E1 associated with paracetamol
10) Confidence 0.50 Published 1997 Journal J. Mol. Med. Section Title Doc Link 9253715 Disease Relevance 0.08 Pain Relevance 0.44
This was more evident in CYP2E1-transfected cells.
Positive_regulation (transfected) of Gene_expression (transfected) of CYP2E1
11) Confidence 0.50 Published 1997 Journal J. Mol. Med. Section Abstract Doc Link 9253715 Disease Relevance 0.09 Pain Relevance 0.47
By transfection of an expression vector of human cytochrome P450 2E1 (CYP2E1) into a human hepatoma cell line (HLE), a new cell line (HLE/2E1) that stably expresses activity of CYP2E1 has been established.
Positive_regulation (transfection) of Gene_expression (transfection) of CYP2E1 associated with hepatocellular cancer
12) Confidence 0.50 Published 2000 Journal In Vitro Cell. Dev. Biol. Anim. Section Abstract Doc Link 11212141 Disease Relevance 0.17 Pain Relevance 0.12
To study the biochemical and toxicological properties of cytochrome P450 2E1 (CYP2E1), an adenovirus containing human CYP2E1 cDNA (Ad-CYP2E1) was constructed and was shown to successfully mediate the overexpression of CYP2E1 in HepG2 cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CYP2E1
13) Confidence 0.50 Published 2004 Journal Mol. Cell. Biochem. Section Abstract Doc Link 15532721 Disease Relevance 0.36 Pain Relevance 0.52
Ethanol has also been shown to increase CYP2E1 gene expression at high doses (> 300 mg/dL blood) (Badger et al. 1993).
Positive_regulation (increase) of Gene_expression (expression) of CYP2E1 in blood
14) Confidence 0.47 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0.09 Pain Relevance 0
To study the biochemical and toxicological properties of cytochrome P450 2E1 (CYP2E1), an adenovirus containing human CYP2E1 cDNA (Ad-CYP2E1) was constructed and was shown to successfully mediate the overexpression of CYP2E1 in HepG2 cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CYP2E1
15) Confidence 0.47 Published 2004 Journal Mol. Cell. Biochem. Section Abstract Doc Link 15532721 Disease Relevance 0.36 Pain Relevance 0.53
In the first step, primers T7CYP2E1 (5?
Positive_regulation (primers) of Gene_expression (primers) of T7CYP2E1
16) Confidence 0.44 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0 Pain Relevance 0
By transfection of an expression vector of human cytochrome P450 2E1 (CYP2E1) into a human hepatoma cell line (HLE), a new cell line (HLE/2E1) that stably expresses activity of CYP2E1 has been established.
Positive_regulation (transfection) of Gene_expression (transfection) of cytochrome P450 2E1 associated with hepatocellular cancer
17) Confidence 0.44 Published 2000 Journal In Vitro Cell. Dev. Biol. Anim. Section Abstract Doc Link 11212141 Disease Relevance 0.17 Pain Relevance 0.12
Cytochrome P450 2E1 (CYP2E1) is one of the
Positive_regulation (Cytochrome) of Gene_expression (one) of CYP2E1
18) Confidence 0.36 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.68 Pain Relevance 0
Chronic administration of alcohol usually induces the synthesis of cytochrome P-450 isoenzyme P-450 II E1, thus accelerating the metabolism of its own and, depending on the circumstances, of various drugs as well.
Positive_regulation (induces) of Gene_expression (synthesis) of cytochrome P-450 isoenzyme P-450 II E1 associated with alcohol
19) Confidence 0.36 Published 1990 Journal Ann. Med. Section Abstract Doc Link 1981316 Disease Relevance 0 Pain Relevance 0.47
We studied the mechanisms of acetaminophen (APAP) cytotoxicity in HepG2 cells overexpressing cytochrome p4502E1, particularly the role of oxidative/nitrosative stress and ryanodine Ca2+ channel.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of cytochrome p4502E1 associated with stress and paracetamol
20) Confidence 0.26 Published 2009 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18751681 Disease Relevance 0.10 Pain Relevance 0.49

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