INT187590

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 4.94
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome segregation (Brca1) intracellular (Brca1) enzyme binding (Brca1)
DNA binding (Brca1) protein complex (Brca1) ligase activity (Brca1)
Anatomy Link Frequency
MCF-7 1
Brca1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 31 91.92 High High
withdrawal 18 53.12 Quite High
Immobilon 6 38.12 Quite Low
anesthesia 3 9.20 Low Low
addiction 18 5.00 Very Low Very Low Very Low
fibrosis 14 5.00 Very Low Very Low Very Low
Inflammation 14 5.00 Very Low Very Low Very Low
palliative 7 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 296 100.00 Very High Very High Very High
Cancer 151 100.00 Very High Very High Very High
Bladder Cancer 2 93.88 High High
Skin Cancer 7 93.12 High High
Ovarian Cancer 25 92.72 High High
Disease 31 92.44 High High
Lymphatic System Cancer 2 92.24 High High
Pancreatic Cancer 1 91.28 High High
Reprotox - General 1 1 90.52 High High
Male Breast Neoplasms 1 87.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATM possesses kinase activity and phosphorylates serine and threonine amino acids in several important downstream cell cycle proteins such as p53, BRCA1/2, CHK1/2 and c-Abl [18,20,21].
Gene_expression (/) of BRCA1
1) Confidence 0.65 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0 Pain Relevance 0
It has been reported that the coding regions of the ATM gene has a reduced nucleotide diversity in human and chimpanzee as compared to other genes such as ABCB1, BRCA1/2, PTGS2 and XRCC1, in particular the last 2650 bp of gene containing among other the PI3K domain [26].
Gene_expression (/) of BRCA1
2) Confidence 0.65 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0.56 Pain Relevance 0
Similarly, the expression of MAK, CBP, and BRCA1 was increased more in LNCaP-ARhi than in LNCaP-pcDNA3.1, and, at least, a 10-fold sensitization was observed.
Gene_expression (expression) of BRCA1
3) Confidence 0.62 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0.14 Pain Relevance 0.03
However, induction of expression in lower concentrations of DHT in LNCaP-ARhi compared to LNCaP-pcDNA3.1 was found in MAK, CBP, AIB1, and BRCA1.
Gene_expression (found) of BRCA1
4) Confidence 0.54 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0 Pain Relevance 0
More specifically, there was no significant reduction in the expression levels of Chk1, Brca1, Topbp1, Rad51, Ddb2, p73, Apaf1, or caspases which were all described to show reduced expression following MCPH1 knockdowns [34] (Tables S3, S4, S5).
Gene_expression (expression) of Brca1
5) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.11 Pain Relevance 0
Our data shows an androgen-mediated induction of the expression of BRCA1.
Gene_expression (expression) of BRCA1
6) Confidence 0.48 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0.62 Pain Relevance 0
However, overexpression of AR enhanced the DHT-stimulated expression of MAK, BRCA1, AIB1 and CBP and reduced the level of expression of ?
Gene_expression (expression) of BRCA1
7) Confidence 0.48 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2518564 Disease Relevance 0.11 Pain Relevance 0
The expression of 25 AR coregulators (SRC1, TIF2, PIAS1, PIASx, ARIP4, BRCA1, ?
Gene_expression (expression) of BRCA1
8) Confidence 0.48 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2518564 Disease Relevance 0.16 Pain Relevance 0
Next, we screened expression of SRC1, TIF2, PIAS1, PIASx, ARIP4, BRCA1, ?
Gene_expression (expression) of BRCA1
9) Confidence 0.48 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0 Pain Relevance 0
expression of other tumor suppressor genes, such as PTEN [22] and BRCA1 [23] through their respective PPRE
Gene_expression (expression) of BRCA1 associated with cancer
10) Confidence 0.45 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 0.78 Pain Relevance 0.08
Current studies using CGH and cDNA microarray analysis suggest a distinct signature of chromosome gains and losses and gene expression for the different classes of familial breast cancers (BRCA1, BRCA2, and BRCAX) compared to sporadic breast cancers.194 BRCA1 appears to interact with the p53 protein (leading to induction of the cell-cycle inhibitor p21Cip1/WAF1; Fig. 1)195 directly, with the RNA polymerase holoenzyme, with the transcription factor CREB, with two proteins termed BAP1 and BARD1, with ER?
Gene_expression (expression) of BRCA1 associated with breast cancer
11) Confidence 0.38 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.29 Pain Relevance 0
increase levels of BRCA1 in MCF-7 breast cancer cells [134].
Gene_expression (levels) of BRCA1 in MCF-7 associated with breast cancer
12) Confidence 0.16 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 1.17 Pain Relevance 0

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