INT1876

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Context Info
Confidence 0.69
First Reported 1976
Last Reported 2010
Negated 3
Speculated 5
Reported most in Abstract
Documents 82
Total Number 87
Disease Relevance 52.16
Pain Relevance 21.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B)
Anatomy Link Frequency
B35 3
Reiter 2
KG-1 1
yolk 1
anterior 1
HLA-B (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 240 100.00 Very High Very High Very High
cytokine 50 99.90 Very High Very High Very High
backache 11 99.88 Very High Very High Very High
spinal inflammation 266 99.76 Very High Very High Very High
spondylitis 23 99.42 Very High Very High Very High
Pain 23 99.36 Very High Very High Very High
psoriasis 39 98.72 Very High Very High Very High
Inflammation 58 96.68 Very High Very High Very High
cINOD 9 96.48 Very High Very High Very High
Lamotrigine 1 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 221 100.00 Very High Very High Very High
Disease 179 100.00 Very High Very High Very High
Syndrome 117 100.00 Very High Very High Very High
Uveitis 28 99.92 Very High Very High Very High
Low Back Pain 276 99.88 Very High Very High Very High
Systemic Lupus Erythematosus 2 99.78 Very High Very High Very High
Chlamydia Infection 182 99.76 Very High Very High Very High
Sacroiliitis 17 99.36 Very High Very High Very High
Pain 17 99.36 Very High Very High Very High
Leukemia 7 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared with 18 774 volunteers, the incidence of HLA-B27 was increased in patients with acute leukaemia (relative risk RR = 1.67, P = 0.002), for both acute myeloid leukaemia (AML) (RR) = 1.67, P = 0.007) and acute lymphoblastic leukaemia (ALL) (RR = 1.68, P = 0.094).
Positive_regulation (increased) of HLA-B27 associated with leukemia and myeloid leukemia
1) Confidence 0.69 Published 2001 Journal Br. J. Haematol. Section Abstract Doc Link 11703328 Disease Relevance 1.27 Pain Relevance 0.33
However, since we detected dimers concomitantly with an increase in overall levels of HLA-B27 heavy-chain dimers, it may be that dimers are normally present at levels below our current detection level, a limitation that we cannot at this stage formally exclude.
Positive_regulation (increase) of HLA-B27
2) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0.36 Pain Relevance 0.13
Whereas it is clear that HLA-B27 is increased in many North American natives, the prevalence varies a great deal.
Positive_regulation (increased) of HLA-B27
3) Confidence 0.63 Published 1998 Journal Curr Opin Rheumatol Section Abstract Doc Link 9725093 Disease Relevance 0.31 Pain Relevance 0.16
By generating the HLA-B27 tetramer (Fig. 1a,1c; lanes 1 and 2) and the HLA-A2 tetramer (Fig. 1b,1c; lanes 3 and 4) the percentages of protein aggregates eluted between 7 and 13 ml in gel filtration, and the refolded monomer eluted at 13.7 ml in gel filtration, were also similar.
Positive_regulation (generating) of HLA-B27 tetramer
4) Confidence 0.55 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064864 Disease Relevance 0.72 Pain Relevance 0
This difference correlates with an opening of the HLA-B*2705 binding groove, accompanied by a partial detachment of the C-terminal peptide anchor.
Positive_regulation (opening) of HLA-B in groove
5) Confidence 0.50 Published 2008 Journal J. Mol. Biol. Section Abstract Doc Link 18178223 Disease Relevance 0.15 Pain Relevance 0.07
HLA-B*2709 differs from the most frequent and disease-associated HLA-B*2705 allele for a single substitution (His vs.
Positive_regulation (disease-associated) of HLA-B associated with disease
6) Confidence 0.49 Published 1995 Journal Eur. J. Immunol. Section Abstract Doc Link 7489765 Disease Relevance 0.67 Pain Relevance 0.32
The HLA-B*2705 and HLA-B*2709 subtypes, whose products differ in only a single amino acid residue of their heavy chains from each other, were primarily chosen for these analyses, but our studies have recently also been extended to the closely related subtypes HLA-B*2703, HLA-B*2704 and HLA-B*2706.
Positive_regulation (extended) of HLA-B
7) Confidence 0.49 Published 2009 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 19731629 Disease Relevance 0.56 Pain Relevance 0.24
The HLA-B*2705 and HLA-B*2709 subtypes, whose products differ in only a single amino acid residue of their heavy chains from each other, were primarily chosen for these analyses, but our studies have recently also been extended to the closely related subtypes HLA-B*2703, HLA-B*2704 and HLA-B*2706.
Positive_regulation (extended) of HLA-B
8) Confidence 0.49 Published 2009 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 19731629 Disease Relevance 0.56 Pain Relevance 0.24
Tests were negative for the HLA-B27 antigen in all 3 patients.
Positive_regulation (negative) of HLA-B27
9) Confidence 0.49 Published 2009 Journal Joint Bone Spine Section Abstract Doc Link 19289294 Disease Relevance 1.02 Pain Relevance 0.08
This concept was thereafter confirmed by the higher prevalence of the HLA-B27 antigen, not only in the group of patients suffering from an axial involvement of ankylosing spondylitis but also in other diseases belonging to the concept of spondyloarthropathy, i.e. psoriatic arthritis, reactive arthritis, inflammatory-bowel-disease-related arthritis and/or other clinical manifestations such as acute anterior uveitis.
Positive_regulation (prevalence) of HLA-B27 in anterior associated with seronegative spondarthritis, spinal inflammation, inflammation, uveitis, disease and arthritis
10) Confidence 0.49 Published 2002 Journal Best Pract Res Clin Rheumatol Section Abstract Doc Link 12406423 Disease Relevance 0.83 Pain Relevance 0.28
[Cross-reacting HLA-B alleles as genetic markers of HLA-B27 negative ankylosing spondylitis].
Positive_regulation ([Cross-reacting) of HLA-B associated with spinal inflammation
11) Confidence 0.49 Published 1986 Journal Z Rheumatol Section Title Doc Link 3492838 Disease Relevance 0.37 Pain Relevance 0.53
The appearance of the HLA-B27 dimer structures later in KG-1.B27.H114D.D116Y cells may reflect its stronger association with tapasin/TAP (Figure 2).
Positive_regulation (appearance) of HLA-B27 in KG-1
12) Confidence 0.48 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575614 Disease Relevance 0 Pain Relevance 0
By generating recombinant HLA-B molecules and studying the eluted peptides by mass spectrometry and pool sequencing, Bade-Doeding et al. (2007) found that residue 95 causes strong alteration of peptide motifs.
Positive_regulation (generating) of HLA-B
13) Confidence 0.47 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2072824 Disease Relevance 0.39 Pain Relevance 0
[The role of HLA-B27 molecules in the pathogenesis of ankylosing spondylitis].
Positive_regulation (role) of HLA-B27 associated with spinal inflammation and cytokine
14) Confidence 0.45 Published 2002 Journal Reumatismo Section Title Doc Link 12404037 Disease Relevance 0.56 Pain Relevance 0.33
This did not depend on whether the target cells were HLA-B27 or not.
Neg (not) Spec (whether) Positive_regulation (depend) of HLA-B27
15) Confidence 0.45 Published 1984 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 6335862 Disease Relevance 0.62 Pain Relevance 0.27
We were able to demonstrate this cross-reactivity in the samples of AAU patients; however, we did find an increased immune complex level that was independent of HLA-B27 antigen.
Neg (independent) Positive_regulation (independent) of HLA-B27 associated with uveitis
16) Confidence 0.45 Published 1982 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 7035395 Disease Relevance 0.85 Pain Relevance 0.24
This is a report of HLA-B27 negative reactive arthritis occurring in two travelers after the administration of oral Ty21a typhoid vaccine.
Positive_regulation (occurring) of HLA-B27 associated with seronegative spondarthritis, typhoid fever and arthritis
17) Confidence 0.45 Published 2000 Journal J Travel Med Section Abstract Doc Link 10689239 Disease Relevance 1.10 Pain Relevance 0.18
We conclude that AS patients in London and Sydney carry the same antigen, that several different incubation media can be used for both the cytotoxicity assay of HLA-B27 positive AS cells and modification of normal B27 positive cells and that the cells used may be collected either in heparin containing media or after defibrination.
Positive_regulation (used) of HLA-B27 associated with spinal inflammation
18) Confidence 0.45 Published 1988 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 3260844 Disease Relevance 0.58 Pain Relevance 0.43
A possible role for beta 2m in the pathogenesis of HLA-B27+ AAU and AS is discussed.
Spec (possible) Positive_regulation (role) of HLA-B27 associated with spinal inflammation and uveitis
19) Confidence 0.45 Published 1990 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 2259876 Disease Relevance 0.87 Pain Relevance 0.45
An increasing demand for HLA-B27 typing as one of the tests used in the diagnosis of ankylosing spondylitis had led us to develop a rapid, automated, flow cytometric assay using whole blood and an HLA-B27 specific monoclonal antibody FD705.
Positive_regulation (increasing) of HLA-B27 in blood associated with spinal inflammation
20) Confidence 0.45 Published 1996 Journal J. Immunol. Methods Section Abstract Doc Link 8890889 Disease Relevance 0.10 Pain Relevance 0.10

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