INT187606

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.05
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.78
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Serpine1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 44 97.18 Very High Very High Very High
cytokine 13 84.76 Quite High
tolerance 23 77.80 Quite High
metalloproteinase 1 73.96 Quite High
fibrosis 44 40.40 Quite Low
agonist 10 15.92 Low Low
Endocannabinoid 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 92 99.24 Very High Very High Very High
Fibrosis 54 98.88 Very High Very High Very High
Ureteral Obstruction 45 98.24 Very High Very High Very High
INFLAMMATION 50 97.18 Very High Very High Very High
Insulin Resistance 16 94.04 High High
Impaired Glucose Tolerance 23 77.80 Quite High
Weight Loss 10 69.32 Quite High
Renal Disease 11 66.16 Quite High
Disorder Of Lipid Metabolism 4 64.24 Quite High
Obesity 42 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As an inflammatory state can lead to fibrotic processes, we analyzed the expression of the pro-fibrotic PAI-1 molecule, and observed that treatment with Hemin reduced the expression of PAI-1 when compared to animals subjected only to UUO (Figure 12A).
Negative_regulation (reduced) of Gene_expression (expression) of PAI-1 associated with fibrosis, ureteral obstruction and inflammation
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 0.87 Pain Relevance 0.17
However, there are also reports of troglitazone treatment reducing the expression of plasminogen activator inhibitor-1 [99,100].
Negative_regulation (reducing) of Gene_expression (expression) of plasminogen activator inhibitor-1
2) Confidence 0.05 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0 Pain Relevance 0.04
For example, lifestyle intervention in subjects participating in the Finnish Diabetes Prevention Study was associated with decreased expression of PAI-1 and fibrinogen, both mediators of fibrinolysis (Hamalainen et al 2005).
Negative_regulation (decreased) of Gene_expression (expression) of PAI-1 associated with diabetes mellitus
3) Confidence 0.01 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291325 Disease Relevance 0.91 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox