INT187612

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.07
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccnd2) nucleolus (Ccnd2) nucleus (Ccnd2)
cell division (Ccnd2) cellular_component (Ccnd2) cytoplasm (Ccnd2)
Ccnd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 9 91.76 High High
cytokine 16 5.00 Very Low Very Low Very Low
Bile 12 5.00 Very Low Very Low Very Low
Inflammation 11 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 8 98.64 Very High Very High Very High
Stress 36 95.68 Very High Very High Very High
Apoptosis 15 87.60 High High
Shock 28 81.60 Quite High
Hyperplasia 1 69.96 Quite High
Ovarian Cancer 9 65.36 Quite High
Granulosa Cell Tumor 1 43.92 Quite Low
Malignant Neoplastic Disease 1 32.88 Quite Low
Benign Tumor 1 30.80 Quite Low
Cancer 8 7.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the 40% CR females showed a significant down-regulation in the gene Ccnd2 (cyclin D2), which is involved in the focal adhesion, JAK-STAT signaling, and cell cycle KEGG pathways.
Regulation (regulation) of Ccnd2 associated with adhesions
1) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.19 Pain Relevance 0
In the 20% CR female animals, there was an up-regulation in Hsd17b4 (17-beta-hydroxysteroid dehydrogenase IV), Gdf9 (Growth/differentiation factor 9), and Ccnd2 (Cyclin D2).
Regulation (regulation) of Cyclin D2
2) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.08 Pain Relevance 0
In the 20% CR female animals, there was an up-regulation in Hsd17b4 (17-beta-hydroxysteroid dehydrogenase IV), Gdf9 (Growth/differentiation factor 9), and Ccnd2 (Cyclin D2).
Regulation (regulation) of Ccnd2
3) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.08 Pain Relevance 0
Interestingly, the 40% CR females showed a significant down-regulation in the gene Ccnd2 (cyclin D2), which is involved in the focal adhesion, JAK-STAT signaling, and cell cycle KEGG pathways.
Regulation (regulation) of cyclin D2 associated with adhesions
4) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.19 Pain Relevance 0
affects cyclin D2.
Regulation (affects) of cyclin D2
5) Confidence 0.05 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.52 Pain Relevance 0.05

General Comments

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