INT187616

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.37
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tendons 2
cartilage 2
Mmp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 137 100.00 Very High Very High Very High
Arthritis 11 98.44 Very High Very High Very High
rheumatoid arthritis 18 97.64 Very High Very High Very High
Inflammation 20 96.40 Very High Very High Very High
cytokine 11 84.56 Quite High
agonist 75 79.52 Quite High
Pain 2 44.76 Quite Low
shoulder pain 4 43.68 Quite Low
Potency 6 8.16 Low Low
Inflammatory mediators 1 7.72 Low Low
Disease Link Frequency Relevance Heat
Experimental Arthritis 6 98.80 Very High Very High Very High
Rheumatoid Arthritis 19 97.64 Very High Very High Very High
INFLAMMATION 26 96.40 Very High Very High Very High
Cancer 11 94.56 High High
Skin Diseases 1 94.16 High High
Cadaver 4 92.92 High High
Arthritis 8 90.48 High High
Disease 18 88.24 High High
Rotator Cuff Tears 60 85.64 High High
Pressure And Volume Under Development 1 73.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, multiple authors have confirmed our findings, of increased MMP 1 and 9 as well as decreased MMP 3 expression in degenerated Achilles tendons [26-28].
Negative_regulation (decreased) of Gene_expression (expression) of MMP 1 in tendons associated with metalloproteinase
1) Confidence 0.44 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.35 Pain Relevance 0.49
Increased MMP 1 and 9 expression, and decreased MMP 3 expression are found in LHB degeneration.
Negative_regulation (decreased) of Gene_expression (expression) of MMP 1 associated with metalloproteinase
2) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2998463 Disease Relevance 0.30 Pain Relevance 0.43
Thus, a decrease of cartilage lesions, associated with a reduction of MMP-1 expression, was reported in the paws of adjuvant arthritis (AA) rats treated with 13-cis RA [14].
Negative_regulation (reduction) of Gene_expression (expression) of MMP-1 in cartilage associated with rheumatoid arthritis, experimental arthritis and arthritis
3) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 1.72 Pain Relevance 0.76
activation can also reduce expression of MMP-13 and MMP-1 by interfering with AP-1 activation [94-96].
Negative_regulation (reduce) of Gene_expression (expression) of MMP-1
4) Confidence 0.02 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0 Pain Relevance 0.04

General Comments

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