INT187617

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Context Info
Confidence 0.06
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.86
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rxrb)
Rxrb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 59 92.88 High High
agonist 97 90.16 High High
palliative 2 79.68 Quite High
corticosteroid 2 73.48 Quite High
cytokine 6 68.88 Quite High
cINOD 19 64.40 Quite High
Inflammatory stimuli 4 33.52 Quite Low
Arthritis 2 24.88 Low Low
Potency 32 5.00 Very Low Very Low Very Low
antagonist 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 32 93.88 High High
Hepatitis C Virus Infection 2 93.16 High High
Death 18 93.04 High High
INFLAMMATION 76 92.88 High High
Hepatocellular Cancer 52 91.28 High High
Hepatitis B Virus Infection 2 88.96 High High
Apoptosis 85 83.56 Quite High
Cancer 42 81.12 Quite High
Colon Cancer 4 71.44 Quite High
Shock 2 55.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
binds, as a heterodimer with retinoid X receptor, to peroxisome-proliferator-response element (PPRE) located in the promoter of numerous target genes whose expression is regulated by PPAR?
retinoid X receptor Binding (binds) of
1) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.57 Pain Relevance 0.42
binds, as a heterodimer with retinoid X receptor, to peroxisome-proliferator-response element (PPRE) located in the promoter of numerous target genes whose expression is regulated by PPAR?
retinoid X receptor Binding (heterodimer) of
2) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.57 Pain Relevance 0.42
then heterodimerizing with the Retinoid X receptor, to finally bind with
Retinoid X receptor Binding (bind) of
3) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 1.43 Pain Relevance 0.19
then heterodimerizing with the Retinoid X receptor, to finally bind with
Retinoid X receptor Binding (heterodimerizing) of
4) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 1.44 Pain Relevance 0.19
, and (3) requirement of identical heterodimer partner, RXR for DNA binding.
RXR Binding (binding) of
5) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.85 Pain Relevance 0.03
The binding affinity of the PPAR/RXR heterodimer is greatly enhanced if the nucleotide between the two hexamers is an adenine, and when there is an AA/TCT sequence 5' of the PPRE (reviewed in [4,5,32]).
RXR Binding (affinity) of
6) Confidence 0.01 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0 Pain Relevance 0.06
These DNA features result in a polarity to the bound heterodimer; PPAR binds to the upstream hexamer while RXR interacts with the lower, 3' hexamer [5,32].
RXR Binding (binds) of
7) Confidence 0.01 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0 Pain Relevance 0.05

General Comments

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