INT187618

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 6.91
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
Anatomy Link Frequency
chondrocytes 1
ovary 1
Ppara (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 239 100.00 Very High Very High Very High
Potency 72 100.00 Very High Very High Very High
Inflammation 136 99.98 Very High Very High Very High
Inflammatory stimuli 6 99.08 Very High Very High Very High
Arthritis 67 98.24 Very High Very High Very High
Inflammatory mediators 3 97.84 Very High Very High Very High
fibrosis 11 97.44 Very High Very High Very High
metalloproteinase 60 96.24 Very High Very High Very High
cytokine 29 86.56 High High
imagery 4 83.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 164 99.98 Very High Very High Very High
Breast Cancer 12 99.44 Very High Very High Very High
Experimental Arthritis 8 98.88 Very High Very High Very High
Apoptosis 34 98.60 Very High Very High Very High
Arthritis 140 98.24 Very High Very High Very High
Coronary Heart Disease 31 97.68 Very High Very High Very High
Weight Gain 8 97.48 Very High Very High Very High
Fibrosis 9 97.44 Very High Very High Very High
Ovarian Cancer 36 96.96 Very High Very High Very High
Body Weight 19 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunolocalization of PPAR?
Localization (Immunolocalization) of PPAR
1) Confidence 0.70 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0 Pain Relevance 0
L RT2 validated PCR primer set for PPAR?
Localization (set) of PPAR
2) Confidence 0.65 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0 Pain Relevance 0.04
However, in the same study, it was shown that treatment with rosiglitazone, a commonly utilized PPAR-?
Localization (utilized) of PPAR
3) Confidence 0.65 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 0.65 Pain Relevance 0.19
However, it is unclear whether PPAR-?
Spec (unclear) Localization (unclear) of PPAR
4) Confidence 0.65 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 1.31 Pain Relevance 0.35
In the presence of PPAR agonists, the inhibitory potency of TGF-?
Localization (presence) of PPAR associated with agonist and potency
5) Confidence 0.64 Published 2010 Journal PPAR Research Section Body Doc Link PMC2957135 Disease Relevance 0 Pain Relevance 0.69
Extraction of proteins and quantification of PPAR?
Localization (quantification) of PPAR
6) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2900215 Disease Relevance 0.05 Pain Relevance 0
These data demonstrate that the highest doses of PPAR-?
Localization (doses) of PPAR
7) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 1.93 Pain Relevance 0.38
inhibited the translocation of PPAR?
Localization (translocation) of PPAR
8) Confidence 0.27 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0 Pain Relevance 0
The biological responses to PPAR agonists are well known to differ between species [56], but our data support the notion that the potency of PPAR?
Localization (potency) of PPAR associated with agonist and potency
9) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.20 Pain Relevance 0.31
Similar pharmacological potencies were reported in chondrocytes [19] and synoviocytes [20] exposed to an inflammatory stimulus, giving a rationale to the anti-inflammatory effect of PPAR?
Localization (effect) of PPAR in chondrocytes associated with inflammation and inflammatory stimuli
10) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.94 Pain Relevance 0.59
However, there are reports of PPAR?
Localization (reports) of PPAR
11) Confidence 0.26 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.25 Pain Relevance 0.12
Support for PPAR?
Localization (Support) of PPAR
12) Confidence 0.26 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 1.16 Pain Relevance 0
The biological responses to PPAR agonists are well known to differ between species [56], but our data support the notion that the potency of PPAR?
Localization (potency) of PPAR associated with agonist and potency
13) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.19 Pain Relevance 0.30
The ability of PPARs to regulate the expression of proteases and angiogenic factors, and the fact that they are expressed in the ovary and in the case of PPAR?
Localization (case) of PPAR in ovary
14) Confidence 0.22 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.23 Pain Relevance 0.11

General Comments

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