INT187627

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 4.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT4) cytoskeleton organization (KRT4)
Anatomy Link Frequency
pancreas 2
horn 1
epidermis 1
epithelial cells 1
stratified squamous epithelial cells 1
KRT4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 42 5.00 Very Low Very Low Very Low
medulla 42 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Chronic pancreatitis 6 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
cryotherapy 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 524 100.00 Very High Very High Very High
Odontogenic Tumors 42 99.92 Very High Very High Very High
Adenocarcinoma 276 99.56 Very High Very High Very High
Follicular Cyst 1 94.72 High High
Transitional Cell Carcinoma 54 94.44 High High
Breast Cancer 66 93.60 High High
Carcinoma 133 87.16 High High
Targeted Disruption 117 85.48 High High
Skin Cancer 174 83.44 Quite High
Recurrence 9 79.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, K4/K13 is completely absent in the epidermis and adnexal structures.
Neg (absent) Gene_expression (absent) of K4 in epidermis
1) Confidence 0.37 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.06 Pain Relevance 0
Our studies indicate that the three cultures express markers of stratified epithelia such as cytokeratin K3, K4, K13, K15, and connexin 43.
Gene_expression (express) of K4
2) Confidence 0.36 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0.07 Pain Relevance 0
Ductal adenocarcinomas of the pancreas in addition often express certain stratified-epithelial keratins, most notably K4 and K17 (Schüssler et al. 1992; Real et al. 1993; Moll 1998).
Gene_expression (express) of K4 in pancreas associated with adenocarcinoma
3) Confidence 0.32 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.03 Pain Relevance 0
As to adenocarcinomas, it is noteworthy to mention the frequent expression of K4 in ductal adenocarcinomas of the pancreas (Schüssler et al. 1992; Real et al. 1993; Moll 1998) and in a subpopulation of poorly differentiated invasive ductal breast carcinomas (Malzahn et al. 1998).


Gene_expression (expression) of K4 in pancreas associated with adenocarcinoma and breast cancer
4) Confidence 0.32 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.90 Pain Relevance 0
K4/K13: keratins of mucosal stratified squamous epithelial cells
Gene_expression (/) of K4 in stratified squamous epithelial cells
5) Confidence 0.32 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.14 Pain Relevance 0
Keratin K4 is also—heterogeneously—expressed in columnar luminal cells of the pseudostratified respiratory epithelium and in the non-stratified simple epithelial cells of e.g. pancreatic ducts (van Muijen et al. 1986; Moll 1993).
Gene_expression (expressed) of Keratin K4 in respiratory
6) Confidence 0.28 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.06 Pain Relevance 0
RT–PCR analysis showed that cultured oral epithelial cells expressed markers of epithelial differentiation such as cytokeratin K3, K4, K13, K15 and connexin 43.
Gene_expression (expressed) of K4 in epithelial cells
7) Confidence 0.28 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
The cells also expressed cytokeratin K4 and K13, markers of nonkeratinized stratified oral epithelia [23,24] as seen earlier in rabbit oral epithelial cultures [16].
Gene_expression (expressed) of cytokeratin K4
8) Confidence 0.28 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254962 Disease Relevance 0 Pain Relevance 0
Focally, there may be expression of K1/K10 (particularly in higher differentiated tumor cells which can end in the formation of horn pearls), and—to a lesser extent—K4 and K13.
Gene_expression (expression) of K4 in horn associated with cancer
9) Confidence 0.25 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.04 Pain Relevance 0
On the other hand the classical AOT is negative for CK4, 10, 13 and 18.
Neg (negative) Gene_expression (negative) of CK4 associated with odontogenic tumors
10) Confidence 0.18 Published 2005 Journal Head Face Med Section Body Doc Link PMC1266042 Disease Relevance 1.25 Pain Relevance 0

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