INT187628

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 11.54
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (KRT14) mitochondrion (KRT14) nucleolus (KRT14)
nucleus (KRT14) intracellular (KRT14) cytoplasm (KRT14)
Anatomy Link Frequency
keratinocytes 2
basal cell 2
dental epithelium 1
cornea 1
myoepithelial cells 1
KRT14 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 83.88 Quite High
Inflammation 69 62.40 Quite High
Potency 10 50.72 Quite High
medulla 70 5.00 Very Low Very Low Very Low
Chronic pancreatitis 10 5.00 Very Low Very Low Very Low
Bile 10 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
iatrogenic 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 947 100.00 Very High Very High Very High
Breast Cancer 230 100.00 Very High Very High Very High
Targeted Disruption 214 99.84 Very High Very High Very High
Odontogenic Tumors 42 99.84 Very High Very High Very High
Epidermolysis Bullosa Simplex 50 98.92 Very High Very High Very High
Congenital Anomalies 12 98.92 Very High Very High Very High
Neuroendocrine Cancer 40 98.48 Very High Very High Very High
Blister 20 96.56 Very High Very High Very High
Lung Cancer 61 95.36 Very High Very High Very High
Skin Cancer 290 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The limbal basal epithelial cells express the keratin pair K5/K14, like most of the undifferentiated cells of the stratified epithelia but are devoid of the cornea-specific keratin pair K3/K12 (Schermer et al 1986).


Gene_expression (express) of K14 in cornea
1) Confidence 0.75 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693999 Disease Relevance 0.06 Pain Relevance 0.07
A similar phenotype found in mice heterozygous for expression of K14/c-Myc and in the NCoA6(NRC)+/- mice suggests that NCoA6(NRC) may play a role in regulating the genes targeted by overexpressed c-Myc.
Gene_expression (expression) of K14
2) Confidence 0.58 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.37 Pain Relevance 0
Otherwise, in the widely well stratified follicular outer root sheath, K5 and K14 are uniformly expressed throughout all layers.
Gene_expression (expressed) of K14
3) Confidence 0.46 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.45 Pain Relevance 0
In addition to their occurrence in keratinocytes, K5 and K14 are expressed in basal and myoepithelial cells of complex and glandular epithelial tissues (Purkis et al. 1990).
Gene_expression (expressed) of K14 in myoepithelial cells
4) Confidence 0.46 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.17 Pain Relevance 0
The expression spectrum of K5 and K14 in tumors corresponds well to the patterns in normal epithelia.
Gene_expression (expression) of K14 associated with cancer
5) Confidence 0.46 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.21 Pain Relevance 0
Neuroendocrine tumors, a large and heterogeneous tumor group, are generally characterized by the expression of keratins typical of simple epithelia (notably K8, K18, and—more variably—K19) and the complete lack of keratins K5/K14 typically found in stratified epithelia.
Gene_expression (expression) of K14 associated with neuroendocrine cancer and cancer
6) Confidence 0.46 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.57 Pain Relevance 0
These patient-related findings were preceded by the experimental demonstration that expression of mutant K14 in transgenic mice causes abnormalities similar to EBS (Vassar et al. 1991).
Gene_expression (expression) of K14 associated with targeted disruption, congenital anomalies and epidermolysis bullosa simplex
7) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.13 Pain Relevance 0
K5/K14: major keratins of basal keratinocytes
Gene_expression (/) of K14 in keratinocytes
8) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.77 Pain Relevance 0
This involves a switch from expression of the basal cell keratins (K5, K14, K15) to the suprabasal epidermal keratins, the type II keratin K1 and subsequently the type I keratin K10 (Fig. 4b; Fuchs and Green 1980; Moll et al. 1982b; Tseng et al. 1982, Weiss et al. 1984; Roop 1987, Stoler et al. 1988).
Gene_expression (expression) of K14 in basal cell
9) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.62 Pain Relevance 0
Most of these tumors strongly express the keratins K5 (Fig. 4c, e), K14 and K17 normally found in the basal layer as well as the keratins K6 (Fig. 4d) and K16 characteristic for hyperproliferative keratinocytes.
Gene_expression (express) of K14 in keratinocytes associated with cancer
10) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.12 Pain Relevance 0
Frequently, K5 and K14 can also be detected in the lower suprabasal cell layers (see above and Fig. 4a).
Gene_expression (detected) of K14
11) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.20 Pain Relevance 0.03
Interestingly, the typical expression profile of the basal-like cancers includes the basal cell-typical keratins K5, K14 and K17.
Gene_expression (expression) of K14 in basal cell associated with cancer
12) Confidence 0.16 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.89 Pain Relevance 0
WalBC cells exhibited expression of known markers of basal invasive human breast cancers as well as increased KRT17, KRT 14 and KRT 19, DSP, s100A4, NDRG-1, ANXA1, TK1 and AQP3 gene expression and decreased gene expression of TIMP3, VIM and TAGLN.
Gene_expression (expression) of KRT 14 associated with breast cancer
13) Confidence 0.09 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2263075 Disease Relevance 0.89 Pain Relevance 0
WalBC cells exhibited expression of known markers of basal invasive human breast cancers as well as increased KRT17, KRT 14 and KRT 19, DSP, s100A4, NDRG-1, ANXA1, TK1 and AQP3 gene expression and decreased gene expression of TIMP3, VIM and TAGLN.
Gene_expression (expression) of KRT 14 associated with breast cancer
14) Confidence 0.09 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2263075 Disease Relevance 0.87 Pain Relevance 0
Recently, Crivelini et al. [19] detected the expression of cytokeratin 14 in AOT and concluded that this probably indicate its origin in the reduced dental epithelium which is also positive for staining with cytokeratin 14 antibodies.
Gene_expression (expression) of cytokeratin 14 in dental epithelium associated with odontogenic tumors
15) Confidence 0.08 Published 2005 Journal Head Face Med Section Body Doc Link PMC1266042 Disease Relevance 1.23 Pain Relevance 0

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