INT187640

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (EGFR, KLF1) intracellular (EGFR, KLF1) DNA binding (KLF1)
extracellular space (EGFR) plasma membrane (EGFR) endosome (EGFR)
EGFR (Homo sapiens)
KLF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 121 98.48 Very High Very High Very High
Pancreatic Cancer 99 94.48 High High
Disease 23 92.32 High High
Breast Cancer 71 88.60 High High
Apoptosis 53 86.88 High High
Adhesions 3 84.52 Quite High
Lung Cancer 4 73.60 Quite High
Glioma 1 73.08 Quite High
Colon Cancer 3 72.12 Quite High
Exanthema 7 70.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monoclonal antibodies interact with the extracellular domain of EGFR, inhibiting EGF ligand binding and inducing receptor endocytosis.
EGFR Binding (interact) of Monoclonal
1) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.66 Pain Relevance 0
Cetuximab is a monoclonal antibody that specifically binds to the EGFR, thereby inhibiting downstream signal transduction pathways [29].
EGFR Binding (binds) of monoclonal
2) Confidence 0.01 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1266352 Disease Relevance 1.13 Pain Relevance 0
Cetuximab, an IgG1 chimeric monoclonal antibody, competes with ligand binding to the EGFR ectodomain, resulting in an efficient blockade of the tumour-promoting downstream signalling pathway.
EGFR Binding (binding) of monoclonal associated with cancer
3) Confidence 0.00 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.76 Pain Relevance 0

General Comments

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