INT187709

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.63
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DBT) small molecule metabolic process (DBT) transferase activity, transferring acyl groups (DBT)
cellular nitrogen compound metabolic process (DBT) cytoplasm (DBT)
Anatomy Link Frequency
capsule 2
MCF-7 2
lutein cells 2
DBT (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 54 99.84 Very High Very High Very High
diclofenac 17 95.76 Very High Very High Very High
COX2 26 94.92 High High
Infliximab 20 93.56 High High
agonist 34 90.64 High High
cytokine 22 75.00 Quite High
Inflammation 5 75.00 Quite High
fibrosis 1 38.20 Quite Low
corticosteroid 8 5.00 Very Low Very Low Very Low
endometriosis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Contracture 10 96.96 Very High Very High Very High
Cancer 24 75.00 Quite High
Necrosis 5 75.00 Quite High
INFLAMMATION 5 75.00 Quite High
Death 5 69.56 Quite High
Apoptosis 25 68.12 Quite High
Reprotox - General 3 38 50.00 Quite Low
Breast Cancer 30 50.00 Quite Low
Fibrosis 3 38.20 Quite Low
Disease 2 36.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both GnRH antagonists had no effect on basal or hCG-induced E2 or progesterone production by granulose lutein cells, independent of whether the cells were exposed to the compounds in vitro or in vivo.
Neg (no) Regulation (effect) of Gene_expression (production) of E2 in lutein cells associated with antagonist
1) Confidence 0.04 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0.39
Influence of ibandronate on the mitogenic effect of E2, and on estrogen receptor regulation and activity in MCF-7 cells
Regulation (Influence) of Gene_expression (effect) of E2 in MCF-7
2) Confidence 0.03 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413981 Disease Relevance 0.30 Pain Relevance 0
specifically modulates the function of MFs through regulation of prostaglandin E2 synthesis and therefore may play a crucial role in the pathogenesis of joint capsule contractures.



Regulation (regulation) of Gene_expression (synthesis) of E2 in capsule associated with contracture
3) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875629 Disease Relevance 0.32 Pain Relevance 0.41

General Comments

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