INT187712

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 2.99
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DBT) small molecule metabolic process (DBT) transferase activity, transferring acyl groups (DBT)
cellular nitrogen compound metabolic process (DBT) cytoplasm (DBT)
Anatomy Link Frequency
follicles 1
endometrium 1
DBT (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 13 98.76 Very High Very High Very High
antagonist 200 94.16 High High
agonist 200 83.04 Quite High
sSRI 7 80.56 Quite High
GABA receptor 1 72.04 Quite High
Opioid 1 71.16 Quite High
GABAergic 6 69.80 Quite High
Dopamine 17 69.20 Quite High
addiction 6 67.44 Quite High
Kinase C 12 66.76 Quite High
Disease Link Frequency Relevance Heat
Post-partum Depression 3 99.20 Very High Very High Very High
Disease 24 95.84 Very High Very High Very High
Adenocarcinoma 9 91.92 High High
Cancer 42 88.72 High High
Reprotox - General 1 108 87.92 High High
Breast Cancer 50 87.16 High High
Lung Cancer 1 85.36 High High
Depression 11 85.32 High High
Skin Cancer 1 84.84 Quite High
Cognitive Disorder 6 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, E2 levels in those who received vaginal injections were maintained at above baseline level after 120 hours with a second peak at 240 hours and then dropped sharply to below baseline level thereafter.
Negative_regulation (dropped) of E2
1) Confidence 0.19 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0
Indeed, either ER expression silencing or E2 deprivation led to a reduction in TRPM8 mRNA expression, and application of E2 increased TRPM8 mRNA.
Negative_regulation (deprivation) of E2
2) Confidence 0.10 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 1.05 Pain Relevance 0
The authors concluded that these findings suggest that the acute reduction in E2 levels during the terminal stage of gonadotropin stimulation had little effect upon follicular recruitment and expansion but an apparent detrimental effect upon gametogenic function may, in fact, exist.
Negative_regulation (reduction) of E2
3) Confidence 0.08 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0
Despite the drastic reduction in the circulating levels of E2 and the increase in the circulating levels of androgens, the overall number of large antral follicles [16 ± 3 for controls and 20 ± 3 for ATD-treated] and their size distribution (as assessed by ultrasonography) proved comparable for control and ATD-treated animals.
Negative_regulation (reduction) of E2 in follicles
4) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0
There were 53% and 70% reductions in the basal and surge levels of E2, respectively without obvious effect on follicular maturation, ovulation, and luteal function as assessed by serum hormone profiles as well as by laparotomy.
Negative_regulation (reductions) of E2
5) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0
-HSD inhibitor, trilostane, led to a reduction in serum E2 levels to 7% of that of control animals throughout the follicular phase.
Negative_regulation (reduction) of E2
6) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.10 Pain Relevance 0
Although it has been proposed that a more rapid decline in E2 is associated with postpartum depression, some recent evidence does not fully support this notion.48 However, treatment with estrogens can relieve some cases of postpartum depression,31,49–51 and some experimental designs that simulate pre- and postpartum estrogen levels also support this conclusion.52 Yet E2 therapy in humans can be ineffective in reversing mood depression or other purportedly estrogen-influenced diseases.50,52–56 One explanation for these discrepancies could be the involvement of other prominent estrogen metabolites [eg, estrone (E1) and estriol (E3); see Figures 1 and 2] that have not been studied nearly as extensively for these activities.
Negative_regulation (decline) of E2 associated with depression, post-partum depression and disease
7) Confidence 0.05 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 1.11 Pain Relevance 0.33
Second, the stimulatory effects of E2 on [Ca2+]i oscillations were blocked by tamoxifen (data not shown), which competes with E2 for binding to ER?
Negative_regulation (effects) of E2
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0.16 Pain Relevance 0.25
While progesterone is an effective anti-estrogen, its role is to reduce ER-alpha concentration rather than to act as a competetive inhibitor of E2 binding, thereby rendering the endometrium resistant to estrogen during the window of implantation.
Negative_regulation (inhibitor) of E2 in endometrium
9) Confidence 0.02 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1679803 Disease Relevance 0 Pain Relevance 0
Compared to E2 administration alone, testosterone reduced E2-induced proliferation by approximately 40% and entirely abolished E2-induced augmentation of estrogen receptor alpha expression [36].
Negative_regulation (abolished) of E2
10) Confidence 0.02 Published 2010 Journal J Cancer Surviv Section Body Doc Link PMC2921487 Disease Relevance 0.31 Pain Relevance 0
GHS-R1a is subject to systemic modulation, including upregulation by thyroxine and E2 and downregulation by glucocorticoids and GH [122].
Negative_regulation (downregulation) of E2
11) Confidence 0.02 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.26 Pain Relevance 0.08

General Comments

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