INT18772

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Context Info
Confidence 0.49
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 2.93
Pain Relevance 5.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
Anatomy Link Frequency
liver 8
1A2 4
PC-12 2
CPA 2
hepatocytes 2
CYP2B6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Buprenorphine 38 99.40 Very High Very High Very High
cva 1 98.40 Very High Very High Very High
endometriosis 5 98.28 Very High Very High Very High
methadone 26 98.12 Very High Very High Very High
agonist 37 97.92 Very High Very High Very High
alcohol 2 97.56 Very High Very High Very High
Paracetamol 14 96.80 Very High Very High Very High
Restless leg syndrome 4 94.48 High High
cINOD 2 91.68 High High
Dismenorea 1 90.36 High High
Disease Link Frequency Relevance Heat
Glioma 18 99.86 Very High Very High Very High
Cancer 86 99.56 Very High Very High Very High
Sprains And Strains 1 98.88 Very High Very High Very High
Cv General 3 Under Development 1 98.40 Very High Very High Very High
Endometriosis (extended) 5 98.28 Very High Very High Very High
Severe Combined Immunodeficiency 3 97.88 Very High Very High Very High
Myocardial Infarction 3 96.60 Very High Very High Very High
Hepatotoxicity 13 95.00 High High
Pox Virus Infection 1 94.80 High High
Increased Venous Pressure Under Development 6 94.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Cytochrome P-450 aromatase expression in the ectopic and eutopic endometrium in endometriosis].
Positive_regulation ([Cytochrome) of Gene_expression (expression) of P-450 in endometrium associated with endometriosis
1) Confidence 0.49 Published 2008 Journal Arkh. Patol. Section Title Doc Link 19137777 Disease Relevance 0.50 Pain Relevance 0.28
Of these, P450 2E1, 1A2, and 3A4 showed substantial activity, with respective Km and Vmax values of 680 microM and 330 pmol/(min.mg) for P450 2E1 (with added cytochrome b5), 3430 microM and 74 pmol/(min.mg) for P450 1A2, and 280 microM and 130 pmol/(min.mg) for P450 3A4.
Positive_regulation (respective) of Gene_expression (with) of P450 in 1A2
2) Confidence 0.49 Published 1993 Journal Chem. Res. Toxicol. Section Abstract Doc Link 8374050 Disease Relevance 0.09 Pain Relevance 0.46
Mammalian PC-12 cell genetically engineered for human cytochrome P450 2E1 expression.
Positive_regulation (engineered) of Gene_expression (expression) of P450 in PC-12
3) Confidence 0.49 Published 1993 Journal Eur. J. Biochem. Section Title Doc Link 8391436 Disease Relevance 0.16 Pain Relevance 0.05
Accordingly, an Ames tester strain was described that was genetically engineered so as to express both aromatic amine N-acetyltransferase and human cytochrome P450 1A2.
Positive_regulation (aromatic) of Gene_expression (express) of P450 in 1A2 associated with sprains and strains
4) Confidence 0.49 Published 1996 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8884021 Disease Relevance 0.35 Pain Relevance 0.09
However, excess mortality has been documented with other phosphodiesterase III inhibitors, especially in patients with heart failure; (7) Cilostazol can provoke dose-dependent cardiac arrhythmias, and sometimes haemorrhage (due to its antiplatelet effect); (8) Cilostazol is extensively metabolised by cytochrome P450 isoenzymes CYP 3A4 and CYP 2C6, creating a high risk of pharmacokinetic interactions with other drugs and with food; (9) In practice, patients with intermittent claudication should not be given cilostazol; they should instead be prescribed an antiplatelet drug and encouraged to stop smoking and to exercise regularly.
Positive_regulation (cytochrome) of Gene_expression (isoenzymes) of P450 in heart associated with nicotine addiction, restless leg syndrome, cva and myocardial infarction
5) Confidence 0.49 Published 2009 Journal Prescrire Int Section Abstract Doc Link 19585717 Disease Relevance 0.59 Pain Relevance 0.36
In human liver microsomes with high and low CYP2B6 expression but equivalent CYP3A4 expression, high CYP2B6 expression microsomes generated twice the amount of EDDP from 10 microg/ml of methadone than low CYP2B6 expression microsomes.
Positive_regulation (generated) of Gene_expression (expression) of CYP2B6 in liver associated with methadone
6) Confidence 0.46 Published 2004 Journal Chirality Section Abstract Doc Link 14628297 Disease Relevance 0 Pain Relevance 1.17
Greater stereoselective metabolism (S > R) occurred in livers expressing high levels of CYP2B6 compared with CYP3A4.
Positive_regulation (levels) of Gene_expression (expressing) of CYP2B6 in livers
7) Confidence 0.45 Published 2008 Journal Anesthesiology Section Body Doc Link 18292673 Disease Relevance 0 Pain Relevance 0
To further clarify the specific isoforms involved, experiments were conducted with preparations expressing only a single P450 isoform (vaccinia virus-expressed cells and microsomes derived from a lymphoblastoid cell line, each transfected with specific P450 cDNAs) as well as inhibition studies using human liver microsomes and putative specific P450 inhibitors.
Positive_regulation (transfected) of Gene_expression (transfected) of P450 in liver
8) Confidence 0.43 Published 1997 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 9248768 Disease Relevance 0 Pain Relevance 0
The metabolism of BUP was examined using human liver microsomes (HLM) and Ad293 P450-transfected cell lines, as well as CYP 3A4 and 2C8 recombinant isoforms.
Spec (examined) Positive_regulation (transfected) of Spec (examined) Gene_expression (transfected) of P450 in liver associated with buprenorphine
9) Confidence 0.26 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15743975 Disease Relevance 0 Pain Relevance 1.12
BUP utilization by either HLM or P450-transfected cells revealed that another oxidative metabolic pathway exists, which was found to involve CYP 2C9, 2C18, 2C19, and mainly CYP 3A.
Positive_regulation (transfected) of Gene_expression (transfected) of P450 associated with buprenorphine
10) Confidence 0.26 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15743975 Disease Relevance 0 Pain Relevance 1.45
In this study, Cyp4a10, a cytochrome P450 involved in lipid metabolism, was induced 14-fold by Wy-14643 (one of the most potent PPAR?
Positive_regulation (induced) of Gene_expression (one) of P450
11) Confidence 0.24 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.07 Pain Relevance 0.35
mm3 sc tumors from 9L glioma cells transduced with CYP2B6 and NADHP450 reductase with CPA (140?
Positive_regulation (with) of Gene_expression (transduced) of CYP2B6 in CPA associated with cancer and glioma
12) Confidence 0.20 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.85 Pain Relevance 0
Human hepatocytes maintained in primary cultures for 72 hr in the presence of 50 microM rifampicin exhibited increased levels of P-450IIIA, determined by Western blot using specific antibodies, and concomitant increase in CsA oxidase activity, determined by HPLC analysis of extra and intracellular media.
Positive_regulation (increased) of Gene_expression (levels) of P-450IIIA in hepatocytes
13) Confidence 0.07 Published 1990 Journal Drug Metab. Dispos. Section Abstract Doc Link 1981707 Disease Relevance 0 Pain Relevance 0
Cytochrome P450 2C9
Positive_regulation (Cytochrome) of Gene_expression (2C9) of P450
14) Confidence 0.06 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.16 Pain Relevance 0.07
Cytochrome P450 2D6
Positive_regulation (Cytochrome) of Gene_expression (2D6) of P450
15) Confidence 0.06 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.15 Pain Relevance 0

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