INT187720

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.99
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYP19A1) small molecule metabolic process (CYP19A1) endoplasmic reticulum (CYP19A1)
cytoplasm (CYP19A1)
Anatomy Link Frequency
body 2
CYP19A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 28 26.24 Quite Low
antagonist 176 5.00 Very Low Very Low Very Low
agonist 138 5.00 Very Low Very Low Very Low
corticosteroid 32 5.00 Very Low Very Low Very Low
dexamethasone 20 5.00 Very Low Very Low Very Low
cva 9 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 3 154 98.84 Very High Very High Very High
Obesity 45 98.36 Very High Very High Very High
Breast Cancer 23 96.20 Very High Very High Very High
Malignant Neoplastic Disease 4 93.76 High High
Reprotox - General 1 52 80.40 Quite High
Immunotherapy Of Cancer 5 75.60 Quite High
Polycystic Ovary Syndrome 48 71.44 Quite High
Recurrence 9 70.24 Quite High
Cancer 34 65.76 Quite High
Suicidal Behaviour 4 57.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second: The aromatase inhibitor was administered EARLY in the follicular phase and for a limited period of time, which would allow the rapid clearance of the aromatase inhibitor from the body due to its SHORT half-life.
Negative_regulation (administered) of Negative_regulation (inhibitor) of aromatase in body
1) Confidence 0.34 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0
However, we have found these aromatase inhibitors to be effective in inhibiting the aromatase enzyme and effectively decrease estrogen levels in women of the reproductive age group during their successful use for ovarian stimulation [417,418,431,432].
Negative_regulation (decrease) of Negative_regulation (inhibitors) of aromatase
2) Confidence 0.33 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.10 Pain Relevance 0
The development of aromatase inhibitors
Negative_regulation (development) of Negative_regulation (inhibitors) of aromatase
3) Confidence 0.33 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.51 Pain Relevance 0
In the last few years, we have worked on the development of aromatase inhibitors for ovarian stimulation and infertility management and reported interesting success in different applications as follows:
Negative_regulation (development) of Negative_regulation (inhibitors) of aromatase associated with reprotox - general 3
4) Confidence 0.33 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.17 Pain Relevance 0
Use of aromatase inhibitors in premenopausal women
Negative_regulation (Use) of Negative_regulation (inhibitors) of aromatase
5) Confidence 0.20 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 0.22 Pain Relevance 0

General Comments

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