INT187721

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 4.69
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) endoplasmic reticulum (PLOD1)
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 7 97.92 Very High Very High Very High
agonist 102 97.44 Very High Very High Very High
antagonist 132 96.16 Very High Very High Very High
endometriosis 28 95.36 Very High Very High Very High
adenocard 14 11.76 Low Low
corticosteroid 24 5.00 Very Low Very Low Very Low
dexamethasone 15 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 312 99.52 Very High Very High Very High
Adhesions 13 99.04 Very High Very High Very High
Dysmenorrhea 7 97.92 Very High Very High Very High
Cancer 133 94.12 High High
Breast Cancer 22 91.96 High High
Apoptosis 16 91.96 High High
Disease 17 85.56 High High
Malignant Neoplastic Disease 31 84.68 Quite High
Ovarian Hyperstimulation Syndrome 33 72.08 Quite High
Metastasis 14 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact we showed that only 35% of patients showed a high expression of LH/hCG mRNA and only these patients responded to exogenous recombinant LH addition by increasing the cell invasion through Matrigel [39].
Transcription (expression) of LH
1) Confidence 0.49 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0.58 Pain Relevance 0
We prospect to analyze herein all the IV stage patients (whose five-year survival is less than 10%) for the expression of LH/hCG mRNA and treat only the high expressors with Gn-RH analogues.



Transcription (expression) of LH
2) Confidence 0.49 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0.38 Pain Relevance 0
The two groups had significantly different levels of LH/hCG-R mRNA expression.
Transcription (expression) of LH
3) Confidence 0.43 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0.88 Pain Relevance 0
Work from Lin et al. [6] showed that the LH/hCG-R mRNA is also expressed in human ECs, and a notion subsequently reinforced by the demonstration that the addition of LH/hCG regulates proliferation in EC cell lines [7, 36].
Transcription (expressed) of LH associated with endometriosis (extended)
4) Confidence 0.43 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0.80 Pain Relevance 0.15
introns; the transcription of the LH/hCG-R gene can produce 7 different protein-coding mRNAs [12–14].
Transcription (transcription) of LH
5) Confidence 0.43 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0 Pain Relevance 0
A good correlation was found between the level of LH/hCG-R mRNA expressed by primary EC and that of LH-induced cell invasiveness in vitro.
Transcription (expressed) of LH associated with endometriosis (extended)
6) Confidence 0.41 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0.77 Pain Relevance 0
Indeed, the LH/hCG-R mRNA is expressed in primary ECs and this expression correlates with LH/hCG-induced cell invasiveness in vitro.
Transcription (expressed) of LH
7) Confidence 0.32 Published 2010 Journal Obstetrics and Gynecology International Section Abstract Doc Link PMC2913851 Disease Relevance 0.95 Pain Relevance 0
Effect on LH tonic pulse during the luteal phase
Transcription (pulse) of LH
8) Confidence 0.14 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.09 Pain Relevance 0.15
Another study (unpublished data) looked at the spontaneous LH surges in seven healthy female volunteers with normal menstrual cycles after a single injection of either 250 ?
Transcription (looked) of LH
9) Confidence 0.12 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.14 Pain Relevance 0.05
Low luteal LH levels have been described after human menopausal gonadotropins treatment6 and after GnRH-agonist treatment or after GnRH-antagonist treatment.
Transcription (described) of luteal LH associated with endometriosis (extended), antagonist and agonist
10) Confidence 0.12 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.10 Pain Relevance 0.17

General Comments

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