INT187726

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.31
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
brain 4
adipose tissue 4
adipocytes 2
upper 2
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 3 95.60 Very High Very High Very High
nud 82 91.40 High High
Dopamine 11 62.52 Quite High
Serotonin 7 58.20 Quite High
Inflammation 31 49.36 Quite Low
Calcium channel 2 44.96 Quite Low
antagonist 49 31.68 Quite Low
agonist 41 29.60 Quite Low
depression 11 19.24 Low Low
Cannabinoid receptor 2 14.68 Low Low
Disease Link Frequency Relevance Heat
Obesity 223 100.00 Very High Very High Very High
Hypertension 37 100.00 Very High Very High Very High
Aging 103 99.76 Very High Very High Very High
Weight Loss 167 99.08 Very High Very High Very High
Injury 6 97.52 Very High Very High Very High
Infection 25 95.52 Very High Very High Very High
Gastritis 1 94.56 High High
Anorexia 4 93.04 High High
Dyspepsia 83 91.40 High High
Diabetes Mellitus 36 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The elevated leptin concentrations seen in obese hypertensive humans are mainly due to abdominal adipose tissue secretion.
Positive_regulation (elevated) of Localization (secretion) of leptin in adipose tissue associated with hypertension and obesity
1) Confidence 0.50 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993994 Disease Relevance 1.26 Pain Relevance 0
Besides increased sympathetic activity, sibutramine treatment in animals and in humans may alter central neuropeptide Y (NPY), and proopiomelanocortin (POMC) mRNA levels and, additionally, the potent anorexigenic hormones leptin and insulin.23,24 Concerning the effects on leptin, it was reported that sibutramine might maintain or even increase leptin transport into the brain during weight loss, while this did not occur during orlistat treatment.25

Studies assessing the weight-lowering potential of sibutramine

Spec (might) Positive_regulation (increase) of Localization (transport) of leptin in brain associated with weight loss and neuropeptide
2) Confidence 0.36 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686261 Disease Relevance 0.75 Pain Relevance 0.11
Signals from the GI tract are sent to the brain to increase the secretion of leptin, resulting in suppressed appetite, energy intake and a delay in gastric emptying.
Positive_regulation (increase) of Localization (secretion) of leptin in brain
3) Confidence 0.17 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3006492 Disease Relevance 0.82 Pain Relevance 0
Moreover, in adipose tissue of women, the estrogen precursors; testosterone and dehydroepiandrosterone also induced an increase in leptin secretion, an effect that was prevented by the aromatase inhibitor letrozole.
Positive_regulation (increase) of Localization (secretion) of leptin in adipose tissue associated with obesity
4) Confidence 0.17 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.26 Pain Relevance 0
Recently, it has been shown that the levels of leptin, a peptide hormone, secreted by adipocytes are elevated with aging more in men than in women.
Positive_regulation (elevated) of Localization (secreted) of leptin in adipocytes associated with aging and obesity
5) Confidence 0.09 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 1.01 Pain Relevance 0
Given that leptin is produced within the stomach to activate vagal-nerve terminals, reduce appetite, and increase mucin secretion, leptin may have a protective role in the upper gut during states of injury [22].
Positive_regulation (increase) of Localization (secretion) of leptin in upper associated with injury
6) Confidence 0.04 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915802 Disease Relevance 1.21 Pain Relevance 0.30

General Comments

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