INT187731

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.30
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DBT) small molecule metabolic process (DBT) transferase activity, transferring acyl groups (DBT)
cellular nitrogen compound metabolic process (DBT) cytoplasm (DBT)
Anatomy Link Frequency
follicles 4
granulosa cells 2
DBT (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 4 55.36 Quite High
cytokine 4 48.00 Quite Low
antagonist 176 5.00 Very Low Very Low Very Low
agonist 136 5.00 Very Low Very Low Very Low
corticosteroid 32 5.00 Very Low Very Low Very Low
endometriosis 28 5.00 Very Low Very Low Very Low
dexamethasone 20 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rupture 8 98.64 Very High Very High Very High
Emergencies 12 90.32 High High
Hemorrhage 4 55.36 Quite High
Edema 24 54.88 Quite High
Reprotox - General 3 152 50.00 Quite Low
Sexual Infantilism 8 47.40 Quite Low
Hypogonadotropic Hypogonadism 4 46.48 Quite Low
Adrenal Cancer 4 38.76 Quite Low
Death 4 32.24 Quite Low
Endometriosis (extended) 52 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They used the aromatase inhibitor, 4-hydroxyandrostenedione (4-OHA), to inhibit endogenous E2 production.
Negative_regulation (inhibit) of Gene_expression (production) of E2
1) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0
Despite the drastic reduction in the circulating levels of E2 and the increase in the circulating levels of androgens, the overall number of large antral follicles [16 ± 3 for controls and 20 ± 3 for ATD-treated] and their size distribution (as assessed by ultrasonography) proved comparable for control and ATD-treated animals.
Negative_regulation (reduction) of Gene_expression (levels) of E2 in follicles
2) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0
In rhesus monkey, supraphysiological doses of estrogen given in the mid or late follicular phase induce atresia or luteinization without rupture of the dominant follicle, reduce the viability of granulosa cells, reduce the synthesis of E2 and progesterone and are detrimental to the oocyte [248].
Negative_regulation (reduce) of Gene_expression (synthesis) of E2 in granulosa cells associated with rupture
3) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.30 Pain Relevance 0.03
Despite this dramatic reduction in E2 levels, neither the total number of large antral follicles per animal (17 ± 1 vs. 18 ± 2) nor their size distribution differed significantly from 3?
Negative_regulation (reduction) of Gene_expression (levels) of E2 in follicles
4) Confidence 0.06 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0

General Comments

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