INT187738

Context Info Confidence 0.64 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 8.13 Pain Relevance 0.64

extracellular space (SELE) cell adhesion (SELE) plasma membrane (SELE)

Anatomy Link Frequency endothelial cells 2 SELE (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 13 100.00 Inflammation 31 98.42 Potency 1 86.36 Inflammatory mediators 2 84.00 ischemia 16 5.00 Inflammatory response 6 5.00 Dopamine 4 5.00 Pain 2 5.00 analgesia 2 5.00 Catecholamine 2 5.00

Disease Link Frequency Relevance Heat Adhesions 48 100.00 Sepsis 134 98.60 INFLAMMATION 34 98.42 Diabetes Mellitus 106 97.96 Coronary Artery Disease 93 97.40 Multiple Organ Failure 14 92.68 Hypoxia 2 91.00 Thrombosis 2 89.72 Pressure Volume 2 Under Development 4 88.68 Disease 31 88.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Put together, therefore, it can be inferred that the presence of the mutant R allele of the E-selectin gene greatly increases the likelihood of patients with DM2 acquiring CAD.

Localization (presence) of E-selectin gene associated with coronary artery disease and diabetes mellitus

1) Confidence 0.64 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.57 Pain Relevance 0.04

The release of cytokines (IL-6, IL-8) and adhesion molecules (soluble endothelial-linked adhesion molecule 1 [sELAM-1], soluble intercellular adhesion molecule 1 [sICAM-1]) has been shown to correlate well with endothelial damage in an experimental setting – especially for sELAM-I, which is specific for endothelial tissue [2,6,7].

Localization (release) of soluble endothelial-linked adhesion molecule 1 associated with adhesions and cytokine

2) Confidence 0.48 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 1.49 Pain Relevance 0.05

The release of cytokines (IL-6, IL-8) and adhesion molecules (soluble endothelial-linked adhesion molecule 1 [sELAM-1], soluble intercellular adhesion molecule 1 [sICAM-1]) has been shown to correlate well with endothelial damage in an experimental setting – especially for sELAM-I, which is specific for endothelial tissue [2,6,7].

Localization (release) of sELAM-1 associated with adhesions and cytokine

3) Confidence 0.48 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 1.50 Pain Relevance 0.05

and bacterial lipopolysaccharide (LPS), increase the expression of cell adhesion molecules (CAMs) including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin on endothelial cells.2 Thus, upon inflammatory stimulation, the endothelial barrier function is rapidly lost and preformed P-selectin is translocated to the luminal surface of endothelial cells, followed by expression and release of E-selectin, ICAM-1, and VCAM-1 – substances that regulate the attachment and trans-endothelial migration of leukocytes.

Localization (release) of selectin in endothelial cells associated with inflammation and adhesions

4) Confidence 0.48 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2828103 Disease Relevance 1.81 Pain Relevance 0.25

and bacterial lipopolysaccharide (LPS), increase the expression of cell adhesion molecules (CAMs) including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin on endothelial cells.2 Thus, upon inflammatory stimulation, the endothelial barrier function is rapidly lost and preformed P-selectin is translocated to the luminal surface of endothelial cells, followed by expression and release of E-selectin, ICAM-1, and VCAM-1 – substances that regulate the attachment and trans-endothelial migration of leukocytes.

Localization (translocated) of selectin in endothelial cells associated with inflammation and adhesions

5) Confidence 0.48 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2828103 Disease Relevance 1.76 Pain Relevance 0.25

General Comments

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