INT187738

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 8.13
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELE) cell adhesion (SELE) plasma membrane (SELE)
Anatomy Link Frequency
endothelial cells 2
SELE (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 13 100.00 Very High Very High Very High
Inflammation 31 98.42 Very High Very High Very High
Potency 1 86.36 High High
Inflammatory mediators 2 84.00 Quite High
ischemia 16 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 48 100.00 Very High Very High Very High
Sepsis 134 98.60 Very High Very High Very High
INFLAMMATION 34 98.42 Very High Very High Very High
Diabetes Mellitus 106 97.96 Very High Very High Very High
Coronary Artery Disease 93 97.40 Very High Very High Very High
Multiple Organ Failure 14 92.68 High High
Hypoxia 2 91.00 High High
Thrombosis 2 89.72 High High
Pressure Volume 2 Under Development 4 88.68 High High
Disease 31 88.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Put together, therefore, it can be inferred that the presence of the mutant R allele of the E-selectin gene greatly increases the likelihood of patients with DM2 acquiring CAD.
Localization (presence) of E-selectin gene associated with coronary artery disease and diabetes mellitus
1) Confidence 0.64 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1933415 Disease Relevance 1.57 Pain Relevance 0.04
The release of cytokines (IL-6, IL-8) and adhesion molecules (soluble endothelial-linked adhesion molecule 1 [sELAM-1], soluble intercellular adhesion molecule 1 [sICAM-1]) has been shown to correlate well with endothelial damage in an experimental setting – especially for sELAM-I, which is specific for endothelial tissue [2,6,7].
Localization (release) of soluble endothelial-linked adhesion molecule 1 associated with adhesions and cytokine
2) Confidence 0.48 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 1.49 Pain Relevance 0.05
The release of cytokines (IL-6, IL-8) and adhesion molecules (soluble endothelial-linked adhesion molecule 1 [sELAM-1], soluble intercellular adhesion molecule 1 [sICAM-1]) has been shown to correlate well with endothelial damage in an experimental setting – especially for sELAM-I, which is specific for endothelial tissue [2,6,7].
Localization (release) of sELAM-1 associated with adhesions and cytokine
3) Confidence 0.48 Published 2005 Journal Crit Care Section Body Doc Link PMC1269435 Disease Relevance 1.50 Pain Relevance 0.05
and bacterial lipopolysaccharide (LPS), increase the expression of cell adhesion molecules (CAMs) including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin on endothelial cells.2 Thus, upon inflammatory stimulation, the endothelial barrier function is rapidly lost and preformed P-selectin is translocated to the luminal surface of endothelial cells, followed by expression and release of E-selectin, ICAM-1, and VCAM-1 – substances that regulate the attachment and trans-endothelial migration of leukocytes.
Localization (release) of selectin in endothelial cells associated with inflammation and adhesions
4) Confidence 0.48 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2828103 Disease Relevance 1.81 Pain Relevance 0.25
and bacterial lipopolysaccharide (LPS), increase the expression of cell adhesion molecules (CAMs) including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin on endothelial cells.2 Thus, upon inflammatory stimulation, the endothelial barrier function is rapidly lost and preformed P-selectin is translocated to the luminal surface of endothelial cells, followed by expression and release of E-selectin, ICAM-1, and VCAM-1 – substances that regulate the attachment and trans-endothelial migration of leukocytes.
Localization (translocated) of selectin in endothelial cells associated with inflammation and adhesions
5) Confidence 0.48 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2828103 Disease Relevance 1.76 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox