INT187739

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.14
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Purkinje cells 2
synapses 2
spike 1
pf (Mus musculus)
Pain Link Frequency Relevance Heat
depression 392 98.24 Very High Very High Very High
potassium channel 7 80.36 Quite High
addiction 21 65.52 Quite High
headache 1 48.96 Quite Low
Inflammatory response 3 22.08 Low Low
Glutamate 8 18.76 Low Low
cva 52 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
Action potential 14 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schoenlein-henoch Purpura 136 100.00 Very High Very High Very High
Meningitis 260 99.92 Very High Very High Very High
Depression 392 98.24 Very High Very High Very High
Death 7 75.84 Quite High
Hemorrhage 17 74.08 Quite High
Body Weight 1 64.12 Quite High
Leukocytosis 1 56.64 Quite High
Sepsis 51 50.00 Quite Low
Meningism 1 50.00 Quite Low
Headache 1 48.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We first studied the recognition of PF activity patterns that had been learned by LTD of AMPA receptor conductances in a biophysically realistic Purkinje-cell model.
PF Binding (recognition) of associated with depression
1) Confidence 0.15 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.35 Pain Relevance 0.18
Purkinje cells in vivo receive a background level of PF activity, which interact with intrinsic pacemaker currents to generate simple-spike firing at frequencies usually between 10 and 100 Hz (Armstrong and Rawson, 1979; Goossens et al., 2001).
PF Binding (interact) of in Purkinje cells
2) Confidence 0.15 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.29 Pain Relevance 0.14
Given that the generation of pauses in the model required sufficient Ca2+ influx into the dendritic tree, pattern recognition based on pause duration is only expected to work for PF patterns with a sufficiently large number of synchronously active synapses.
PF Binding (recognition) of in synapses
3) Confidence 0.14 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.17 Pain Relevance 0.12
After the induction protocol, we monitored pause duration for 30–40 min then repatched the same cell and recorded PF EPSPs (Figure 4E, bottom left) and CF responses (Figure 4E, bottom right) in whole-cell mode.
PF Binding (recorded) of
4) Confidence 0.14 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.21 Pain Relevance 0.10
This raises the question of which features of the Purkinje-cell spike train could be used for recognizing learned PF patterns.
PF Binding (recognizing) of in spike
5) Confidence 0.13 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.32 Pain Relevance 0.16
A recent study of pattern storage in Purkinje cells (Brunel et al., 2004) has suggested that each Purkinje cell could learn to recognize approximately 40000 different PF input patterns.
PF Binding (recognize) of in Purkinje cell
6) Confidence 0.13 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0 Pain Relevance 0.03
Up to now we have assumed that a Purkinje cell has to recognize PF activity patterns composed of the synchronous activation of a number of PF synapses.
PF Binding (recognize) of in synapses
7) Confidence 0.13 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.24 Pain Relevance 0.12
Deeper within TM2, measurements of relative calcium permeability [38] and Pf% [39] clearly identify Thr336, Thr339 and Ser340 as providing side chains that interact with permeating calcium ions.
Pf Binding (interact) of
8) Confidence 0.02 Published 2010 Journal Trends in Pharmacological Sciences Section Body Doc Link PMC2954318 Disease Relevance 0 Pain Relevance 0
Both study case report forms and investigator reports of serious adverse events were interrogated for medical and microbiological terms associated with PF, MEN, or MD.
PF Binding (associated) of associated with schoenlein-henoch purpura and meningitis
9) Confidence 0.01 Published 2005 Journal Crit Care Section Body Doc Link PMC1269439 Disease Relevance 1.55 Pain Relevance 0

General Comments

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