INT18774

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Context Info
Confidence 0.65
First Reported 1982
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 67
Total Number 70
Disease Relevance 47.66
Pain Relevance 37.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RYBP) nucleus (RYBP) intracellular (RYBP)
DNA binding (RYBP) cytoplasm (RYBP)
Anatomy Link Frequency
E1a 15
plasma 8
liver 3
hepatocyte 2
kidney 2
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 729 100.00 Very High Very High Very High
Bile 8 99.44 Very High Very High Very High
Analgesic 15 98.40 Very High Very High Very High
depression 8 96.52 Very High Very High Very High
aspirin 6 96.20 Very High Very High Very High
Inflammation 33 95.84 Very High Very High Very High
Potency 21 89.16 High High
anesthesia 1 87.24 High High
palliative 23 85.04 High High
transdermal 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 1386 100.00 Very High Very High Very High
Infection 551 100.00 Very High Very High Very High
Cancer 1964 99.96 Very High Very High Very High
Biliary Cancer 8 99.68 Very High Very High Very High
Necrosis 14 99.60 Very High Very High Very High
Injury 26 99.54 Very High Very High Very High
Anaemia 23 99.36 Very High Very High Very High
Liver Failure 1 99.36 Very High Very High Very High
Cholangiocarcinoma 29 99.28 Very High Very High Very High
Renal Disease 6 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The production of 3-nitro-APAP would only account for a few percents of the total transformation rate of APAP in WWTPs.
Gene_expression (production) of APAP associated with paracetamol
1) Confidence 0.65 Published 2010 Journal Environ. Sci. Technol. Section Abstract Doc Link 19994883 Disease Relevance 0 Pain Relevance 0.85
Voltammetric detection of APAP in vivo was complicated with normal electrodes by interference from pH changes.
Gene_expression (detection) of APAP
2) Confidence 0.65 Published 2000 Journal J. Neurosci. Methods Section Abstract Doc Link 10752479 Disease Relevance 0 Pain Relevance 0.09
In contrast, nitric oxide (*NO) produced by nitrifying bacteria is probably involved in APAP nitration through the formation of peroxynitrite in presence of superoxide anion.
Gene_expression (nitration) of APAP associated with paracetamol
3) Confidence 0.65 Published 2010 Journal Environ. Sci. Technol. Section Abstract Doc Link 19994883 Disease Relevance 0 Pain Relevance 0.86
Moreover, the concentration of hepatic APAP-protein adducts formed in these mice was only 10% that in control mice.
Gene_expression (adducts) of APAP-protein associated with paracetamol
4) Confidence 0.59 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20036646 Disease Relevance 1.04 Pain Relevance 1.00
A rapid membrane and gold particle-based immunoassay for the simultaneous detection of APAP and ASA has been developed.
Gene_expression (detection) of APAP
5) Confidence 0.58 Published 2003 Journal J Anal Toxicol Section Abstract Doc Link 14516490 Disease Relevance 0.19 Pain Relevance 0.20
By contrast, hepatic microsomal production of the APAP conjugate was not changed by castration.
Gene_expression (production) of APAP associated with paracetamol
6) Confidence 0.58 Published 1994 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 8209379 Disease Relevance 0.39 Pain Relevance 1.21
In addition, plasma levels of APAP and its sulfate and glucuronide conjugates were determined after 6 h.
Gene_expression (levels) of APAP in plasma associated with paracetamol
7) Confidence 0.58 Published 1986 Journal Arch. Toxicol. Section Abstract Doc Link 3827589 Disease Relevance 0.16 Pain Relevance 0.65
Blood levels of APAP had the same relationship.
Gene_expression (levels) of APAP in Blood associated with paracetamol
8) Confidence 0.58 Published 1988 Journal Toxicol. Lett. Section Abstract Doc Link 3263718 Disease Relevance 0.33 Pain Relevance 1.29
This pilot study suggests that patients with no risk factors and APAP levels in the "possible risk" range may not require NAC therapy.
Gene_expression (levels) of APAP associated with paracetamol
9) Confidence 0.58 Published 1996 Journal J Emerg Med Section Abstract Doc Link 8969987 Disease Relevance 0.76 Pain Relevance 0.59
Significantly more 14C-labeled APAP protein adduct was detected in MVh2E1-9 cells than MV-5 cells, especially after depletion of GSH.
Gene_expression (detected) of APAP associated with paracetamol
10) Confidence 0.51 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791125 Disease Relevance 0.22 Pain Relevance 1.12
An electrophilic metabolite of APAP produced by the kidney may initiate APAP induced renal necrosis.
Gene_expression (produced) of APAP in kidney associated with necrosis and paracetamol
11) Confidence 0.50 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6278138 Disease Relevance 0.15 Pain Relevance 0.92
These data suggest that the kidney can produce an electrophilic metabolite of APAP which can combine with and deplete renal GSH.
Gene_expression (produce) of APAP in kidney associated with paracetamol
12) Confidence 0.50 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6278138 Disease Relevance 0.06 Pain Relevance 1.00
Two different types of soft alkyl ether prodrugs incorporating ethyleneoxy groups into the promoiety have been synthesized for a model phenol (acetaminophen, APAP): alkyloxycarbonyloxymethyl type (AOCOM) and N-alkyl-N-alkyloxycarbonyl-aminomethyl type (NANAOCAM).
Gene_expression (synthesized) of APAP associated with paracetamol
13) Confidence 0.50 Published 2009 Journal Molecules Section Abstract Doc Link 19924060 Disease Relevance 0 Pain Relevance 0.14
However, little, if any, APAP-GSH is found in the urine of intact animals.
Gene_expression (found) of APAP-GSH in urine
14) Confidence 0.48 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2871175 Disease Relevance 0 Pain Relevance 0.17
Expression of apoptin by means of plasmids caused extensive cell death in three independent cholangiocarcinoma cell lines, CC-LP, CC-SW, and Mz-ChA-1, regardless of their oncogenic mutations, which included inactivated p16 and p53 and the disruption of the transforming growth factor beta signaling pathway.
Gene_expression (Expression) of apoptin associated with cholangiocarcinoma and death
15) Confidence 0.45 Published 2004 Journal J. Mol. Med. Section Abstract Doc Link 14647920 Disease Relevance 1.09 Pain Relevance 0.09
Moreover, coexpression of the broad-spectrum caspase inhibitor p35 with apoptin only delayed the induced cell death.
Gene_expression (coexpression) of apoptin associated with death
16) Confidence 0.45 Published 2004 Journal J. Mol. Med. Section Abstract Doc Link 14647920 Disease Relevance 1.33 Pain Relevance 0.07
APAP-GSH production was increased significantly when the cytosolic fraction from saline-treated mice and/or microsomes from DMSO-treated mice were used.
Gene_expression (production) of APAP associated with paracetamol
17) Confidence 0.44 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880615 Disease Relevance 0.27 Pain Relevance 0.90
Generation of APAP-GSH in microsomes from control mice was inhibited by DMSO in a dose-dependent manner.
Gene_expression (Generation) of APAP associated with paracetamol
18) Confidence 0.39 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880615 Disease Relevance 0.23 Pain Relevance 0.96
Quantification of major APAP metabolites in plasma showed that APAP-glutathione (GSH), a conjugate generated via metabolic activation of APAP, was reduced significantly while APAP-sulfate and APAP-glucuronide, detoxified metabolites both produced directly from the parent drug, were increased in mice pretreated with DMSO.
Gene_expression (produced) of APAP-glucuronide in plasma associated with paracetamol
19) Confidence 0.39 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880615 Disease Relevance 0.25 Pain Relevance 0.96
Quantification of major APAP metabolites in plasma showed that APAP-glutathione (GSH), a conjugate generated via metabolic activation of APAP, was reduced significantly while APAP-sulfate and APAP-glucuronide, detoxified metabolites both produced directly from the parent drug, were increased in mice pretreated with DMSO.
Gene_expression (produced) of APAP in plasma associated with paracetamol
20) Confidence 0.39 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880615 Disease Relevance 0.25 Pain Relevance 0.97

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