INT187741

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 33
Total Number 33
Disease Relevance 12.38
Pain Relevance 7.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
synapses 19
dendrites 2
molecular layer 1
spikes 1
dendritic tree 1
pf (Mus musculus)
Pain Link Frequency Relevance Heat
depression 1380 99.92 Very High Very High Very High
Glutamate receptor 504 98.96 Very High Very High Very High
long-term potentiation 60 97.72 Very High Very High Very High
Glutamate 48 95.32 Very High Very High Very High
addiction 60 90.64 High High
potassium channel 12 89.84 High High
Hippocampus 18 85.72 High High
nMDA receptor 24 76.52 Quite High
Thalamus 24 73.92 Quite High
Action potential 72 71.68 Quite High
Disease Link Frequency Relevance Heat
Meningitis 520 100.00 Very High Very High Very High
Schoenlein-henoch Purpura 272 100.00 Very High Very High Very High
Sepsis 102 99.98 Very High Very High Very High
Depression 1380 99.92 Very High Very High Very High
Adhesions 60 99.74 Very High Very High Very High
Disease 12 98.70 Very High Very High Very High
Ataxia 9 97.92 Very High Very High Very High
Repression 13 96.96 Very High Very High Very High
Targeted Disruption 18 94.80 High High
Hemorrhage 34 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inputs were randomly distributed over the dendritic tree in the model, but PF stimulation is likely to result in the activation of PF synapses confined to a smaller area of the Purkinje-cell dendrite.
Gene_expression (synapses) of PF in dendrite
1) Confidence 0.29 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0 Pain Relevance 0.04
Learning of patterns was implemented as a reduction of the AMPA receptor conductances of activated PF synapses, as is the case after induction of LTD (see Experimental Procedures).
Gene_expression (synapses) of PF in synapses associated with depression
2) Confidence 0.29 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.44 Pain Relevance 0.22
In the first instance, we studied patterns in which 1000 randomly distributed PF synapses were activated synchronously.
Gene_expression (synapses) of PF in synapses
3) Confidence 0.25 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.37 Pain Relevance 0.19
The inhibitory input followed the synchronous activation of excitatory PF synapses with a delay of 1.4 ms (Mittmann et al., 2005) and had a rise time constant of 1 ms and a decay time constant of 8 ms (W.M. and M.H., unpublished data).


Gene_expression (synapses) of PF in synapses
4) Confidence 0.25 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0 Pain Relevance 0
PF patterns that had been learned by LTD resulted in less Ca2+ influx into the dendritic tree of the model.
Gene_expression (learned) of PF in dendritic tree associated with depression
5) Confidence 0.25 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.23 Pain Relevance 0.16
In the full Purkinje-cell model, each of the 147,400 spine heads contained one PF synapse.
Gene_expression (synapse) of PF in synapse
6) Confidence 0.25 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.07 Pain Relevance 0.07
The resulting LTD of the PF synapses is assumed to lead to a decreased rate of Purkinje-cell simple-spike firing, a reduction in the inhibition of their target neurons in the deep cerebellar nuclei (DCN), and thus an increased output from the cerebellum (Boyden et al., 2006; Hansel et al., 2001; Ito, 1984; Ito, 1989; Ito, 2001; Jorntell and Hansel, 2006; Koekkoek et al., 2003; Mauk et al., 1998; Ohyama et al., 2003; Thompson and Krupa, 1994).
Gene_expression (synapses) of PF in cerebellum associated with depression
7) Confidence 0.25 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.27 Pain Relevance 0.13
In a set of control simulations, the number of active PF synapses per pattern was varied, and in another set of simulations, the active inputs were desynchronized by random distribution of them over time windows of up to 25 ms.
Gene_expression (synapses) of PF in synapses
8) Confidence 0.25 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.08 Pain Relevance 0.04
Before learning, all PF synapses of the Purkinje-cell model activated the same maximum AMPA receptor conductance g¯0=0.7nS (De Schutter and Bower, 1994b).
Gene_expression (synapses) of PF in synapses
9) Confidence 0.25 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0 Pain Relevance 0
Purkinje cells receive PF synapses on approximately 150,000 dendritic spines (Harvey and Napper, 1991).
Gene_expression (synapses) of PF in spines
10) Confidence 0.25 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.14 Pain Relevance 0.14
On the basis of simulations where combined excitatory and inhibitory background input resulted in continuous simple-spike firing as observed in vivo (De Schutter and Bower, 1994b; Jaeger et al., 1997), the model predicted that synchronized PF inputs trigger a short burst of spikes followed by a pause.
Gene_expression (synchronized) of PF in spikes
11) Confidence 0.25 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.29 Pain Relevance 0.15
The model was presented with 75 of such PF patterns that had been learned by LTD, and its response was compared to the response to 75 novel patterns.
Gene_expression (learned) of PF associated with depression
12) Confidence 0.25 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.32 Pain Relevance 0.16
2 alone promotes the formation of PF synaptic contacts and PF presynaptic differentiation, we suggest that it generates PF-PC synapses in these compartments.
Gene_expression (generates) of PF in synapses
13) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0.08 Pain Relevance 0.04
2 not only stabilizes PF synapses but also limits CF innervation to the PC proximal dendritic domain [7].
Gene_expression (synapses) of PF in proximal
14) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0.54 Pain Relevance 0.08
2 in PC-PF synapses regulates their maturation and strengthening and induces long term depression (LTD).
Gene_expression (synapses) of PF in synapses associated with depression
15) Confidence 0.24 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2666267 Disease Relevance 0.46 Pain Relevance 0.18
2 acts as an adhesion molecule in PF synaptogenesis.
Gene_expression (synaptogenesis) of PF associated with adhesions
16) Confidence 0.24 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2666267 Disease Relevance 0.43 Pain Relevance 0.16
The PF synapses progressively restrict the surrounding CF territory, and as a consequence, the lateral inhibition that is exerted by the CFs is reduced, intrinsic spinogenesis develops, and new spines that express GluR?
Gene_expression (synapses) of PF in synapses
17) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0.14 Pain Relevance 0.03
Recovery of PF-PC synaptic contacts in the distal dendritic compartment in hotfoot mice
Gene_expression (Recovery) of PF
18) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0 Pain Relevance 0
Gold particles representing AMPA receptors were detected on the postsynaptic membrane of PF-PC synapses in both genotypes (Fig. 2F).
Gene_expression (synapses) of PF-PC in synapses
19) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.08 Pain Relevance 0.27
When quantified, the number of gold particles of AMPA receptors per profile of PF-PC synapses in the mutant mice (6.4±0.3, n?
Gene_expression (synapses) of PF-PC in synapses
20) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.09 Pain Relevance 0.27

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