INT18778

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Context Info
Confidence 0.35
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 9.91
Pain Relevance 6.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a2) enzyme binding (Ugt1a2)
Anatomy Link Frequency
joints 2
bar 1
plasma 1
leukocyte 1
nerve 1
Ugt1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
b2 receptor 62 100.00 Very High Very High Very High
gABA 6 99.98 Very High Very High Very High
dorsal root ganglion 642 99.80 Very High Very High Very High
Dorsal horn neuron 2 99.68 Very High Very High Very High
Pain threshold 9 99.54 Very High Very High Very High
bradykinin 248 99.52 Very High Very High Very High
Neuropathic pain 5 98.08 Very High Very High Very High
Spinal cord 15 97.60 Very High Very High Very High
B1 receptor 1 97.60 Very High Very High Very High
agonist 10 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 642 99.80 Very High Very High Very High
Adhesions 3 99.66 Very High Very High Very High
Pain 70 99.54 Very High Very High Very High
Disease 19 99.14 Very High Very High Very High
Pancreatitis 18 99.04 Very High Very High Very High
Lung Injury 26 98.94 Very High Very High Very High
Apoptosis 37 98.92 Very High Very High Very High
Gallstones 3 98.50 Very High Very High Very High
Neuropathic Pain 5 98.08 Very High Very High Very High
Increased Venous Pressure Under Development 3 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B2 receptors are responsible for most of the kinins' biological effects, including arterial vasodilatation, plasma extravasation, venoconstriction, activation of sensory fibers (e.g., fibers for pain), and stimulation of the release of prostaglandins, endothelium-dependent relaxing factor (from endothelia), noradrenaline (from nerve terminals and adrenals), and other endogenous agents.
Gene_expression (responsible) of B2 in plasma associated with pain, noradrenaline and increased venous pressure under development
1) Confidence 0.35 Published 1993 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8306193 Disease Relevance 0.41 Pain Relevance 0.51
In vitro studies have demonstrated the ability of NCX-4016 to interfere with platelet aggregation, adhesion and thromboxane B2 production.
Gene_expression (production) of B2 in platelet associated with adhesions
2) Confidence 0.31 Published 1998 Journal IDrugs Section Abstract Doc Link 18465536 Disease Relevance 0.47 Pain Relevance 0.41
UDPGT activity towards bilirubin, although induced by PB, can be detected in hepatic, intestinal and renal microsomes.
Gene_expression (detected) of UDPGT
3) Confidence 0.30 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3096339 Disease Relevance 0.07 Pain Relevance 0.10
The experiments also demonstrate that daily administration (10 mg/kg, i.p.) of amitriptyline, a tricyclic antidepressant used for the treatment of neuropathic pain, for 1 week after surgery prevents the decline in thermal pain threshold, the increase in GABA(B2) gene expression, and development of increased GABA(B) receptor function in spinal cord resulting from nerve damage.
Gene_expression (expression) of B2 in nerve associated with gaba, pain threshold, nervous system injury, neuropathic pain, tricyclic antidepressant, endep and spinal cord
4) Confidence 0.29 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16293232 Disease Relevance 0.75 Pain Relevance 1.50
Compared to co-cultures of DRG neurones and FLS cells from normal joints, a significantly higher proportion of DRG neurones (on average, 69.5 ± 9.9% of the DRG neurones, 4 cultures) showed B2 receptor expression when FLS cells from acutely inflamed knee joints were used for co-culture (Figure 4c, third bar).
Gene_expression (expression) of B2 in joints associated with dorsal root ganglion and b2 receptor
5) Confidence 0.22 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 1.11 Pain Relevance 0.87
Expression of NK1, B2, and TRPV1 receptor-like IR in DRG neurones after co-culture with FLS cells
Gene_expression (Expression) of B2 associated with dorsal root ganglion
6) Confidence 0.22 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.87 Pain Relevance 0.48
Influence of soluble FLS cell mediators on the expression of NK1, B2, and TRPV1 receptors
Gene_expression (expression) of B2
7) Confidence 0.22 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.61 Pain Relevance 0.31
Serum levels of bilirubin and amylase were determined by radioimmunoassay.
Gene_expression (levels) of bilirubin
8) Confidence 0.20 Published 2010 Journal Saudi Med J Section Body Doc Link 20062892 Disease Relevance 0.08 Pain Relevance 0
The upregulation of NK1 receptor-like IR by FLS cells from acutely inflamed joints was mimicked by the supernatant of FLS cells from acutely inflamed joints, but the expression of neither B2 nor TRPV1 receptors was influenced by supernatants from FLS cells from normal, acutely or chronically inflamed knee joints.
Gene_expression (expression) of B2 in joints
9) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.38 Pain Relevance 0.22
Thus, in contrast with NK1 receptor expression, FLS cells from normal knee joints caused a significant up-regulation of the proportion of DRG neurones exhibiting B2 receptor-like labelling (Figure 4c, second bar).
Gene_expression (exhibiting) of B2 in bar associated with dorsal root ganglion and b2 receptor
10) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.95 Pain Relevance 0.78
To examine whether the binding was related to B2 receptors, 3 nmol/ml BK-gold was incubated in parallel control dishes in the presence of 1 ?
Gene_expression (receptors) of B2 associated with bradykinin
11) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0 Pain Relevance 0.36
We now show that the B2 kinin receptor is expressed in rat dorsal horn neurons and that bradykinin, a B2-specific agonist, augments AMPA- and NMDA-induced, and primary afferent-evoked EPSCs, and increases the frequency and amplitude of miniature EPSCs in superficial dorsal horn neurons in vitro.
Gene_expression (expressed) of B2 in dorsal horn associated with agonist, bradykinin and dorsal horn neuron
12) Confidence 0.18 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16135755 Disease Relevance 0.49 Pain Relevance 0.94
The number of condensed nuclei demonstrating apoptosis was significantly increased with the increasing METH concentrations (Fig. 3A, b2 and c2, indicated by arrow; Fig. 3B).
Gene_expression (concentrations) of b2 associated with apoptosis
13) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677674 Disease Relevance 0.76 Pain Relevance 0
Gunn rats, which are genetically deficient in bilirubin glucuronidation, were able to form acylglucuronides from the drugs, thus indicating that these 2-arylpropionic acids were not substrates of the bilirubin isozyme.
Gene_expression (substrates) of bilirubin isozyme
14) Confidence 0.04 Published 1990 Journal Drug Metab. Dispos. Section Abstract Doc Link 1981722 Disease Relevance 0.05 Pain Relevance 0.09
In disease states Oxy-Hemoglobin, Met-Hemoglobin and Bilirubin can be identified in cerebrospinal fluid.
Gene_expression (identified) of Bilirubin in cerebrospinal fluid associated with disease
15) Confidence 0.03 Published 1989 Journal Nervenarzt Section Abstract Doc Link 2739818 Disease Relevance 1.01 Pain Relevance 0.31
And it increased W/D ratio of lung, lung injury score and leukocyte count, percentage of PMN cells, concentration of albumin, thromboxane B2 and IL-8 in BALF.
Gene_expression (concentration) of B2 in leukocyte associated with lung injury
16) Confidence 0.02 Published 2004 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2822264 Disease Relevance 0.41 Pain Relevance 0
The wet weight/dry weight (W/D) ratio of lung and lung injury score of the lung, and number of leukocyte, percent of polymorphonuclear neutrophil (PMN) cells, concentration of albumin, thromboxane B2 (TxB2), and IL-8 in bronchoalveolar lavage fluid (BALF) were measured.


Gene_expression (concentration) of B2 in polymorphonuclear neutrophil associated with lung injury
17) Confidence 0.02 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822264 Disease Relevance 0.37 Pain Relevance 0
The diagnosis of gallstone-induced acute pancreatitis can be made by combining detection of elevated levels of bilirubin, transamylase (ALT, AST) and ALP detected by hematological examination and the visualization of gallstones by US.
Gene_expression (levels) of bilirubin associated with pancreatitis and gallstones
18) Confidence 0.01 Published 2010 Journal J Hepatobiliary Pancreat Sci Section Abstract Doc Link 20012328 Disease Relevance 1.12 Pain Relevance 0

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